Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
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DOI: 10.1002/2211-5463.13371
Abstract: Mitochondrial calcium homeostasis plays critical roles in cell survival and aerobic metabolism in eukaryotes. The calcium uniporter is a highly selective calcium ion channel consisting of several subunits. Mitochondrial calcium uniporter (MCU) and essential MCU… read more here.
Keywords: mcu; calcium uniporter; mcu emre; emre ... See more keywords
The mitochondrial calcium uniporter complex in trypanosomes
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DOI: 10.1002/cbin.10928
Abstract: The presence of a conserved mechanism for mitochondrial calcium uptake in trypanosomatids was crucial for the molecular identification of the mitochondrial calcium uniporter (MCU), a long‐sought channel present in most eukaryotic organisms. Since then, research… read more here.
Keywords: calcium uniporter; complex trypanosomes; uniporter complex; mitochondrial calcium ... See more keywords
Structure-Activity Relationships of Metal-Based Inhibitors of the Mitochondrial Calcium Uniporter.
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DOI: 10.1002/cmdc.202300106
Abstract: The mitochondrial calcium uniporter (MCU) is a transmembrane protein that is responsible for mediating mitochondrial calcium (mCa2+) uptake. Given this critical function, the MCU has been implicated as an important target for addressing various human… read more here.
Keywords: calcium uniporter; metal based; metal; mitochondrial calcium ... See more keywords
Patch-Clamp Analysis of the Mitochondrial Calcium Uniporter.
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DOI: 10.1007/978-1-4939-9018-4_7
Abstract: Mitochondria accumulate significant amounts of calcium when cytosolic calcium is elevated above the resting levels of 50-100 nM during signaling events. This calcium uptake is primarily mediated by a macromolecular protein assembly called mitochondrial calcium uniporter… read more here.
Keywords: calcium; calcium uniporter; patch clamp; mitochondrial calcium ... See more keywords
Metabolite regulation of the mitochondrial calcium uniporter channel.
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DOI: 10.1016/j.ceca.2020.102288
Abstract: Calcium (Ca2+) is known to stimulate mitochondrial bioenergetics through the modulation of TCA cycle dehydrogenases and electron transport chain (ETC) complexes. This is hypothesized to be an essential pathway of energetic control to meet cellular… read more here.
Keywords: mitochondrial bioenergetics; uniporter channel; calcium uniporter; mitochondrial calcium ... See more keywords
S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter
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DOI: 10.1038/s41598-020-65994-y
Abstract: The mitochondrial calcium uniporter (MCU) plays essential roles in mitochondrial calcium homeostasis and regulates cellular functions, such as energy synthesis, cell growth, and development. Thus, MCU activity is tightly controlled by its regulators as well… read more here.
Keywords: s92 phosphorylation; calcium uniporter; mitochondrial calcium; s92 ... See more keywords
Evidence supporting the MICU1 occlusion mechanism and against the potentiation model in the mitochondrial calcium uniporter complex.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217665120
Abstract: The mitochondrial calcium uniporter is a Ca2+ channel that imports cytoplasmic Ca2+ into the mitochondrial matrix to regulate cell bioenergetics, intracellular Ca2+ signaling, and apoptosis. The uniporter contains the pore-forming MCU subunit, an auxiliary EMRE… read more here.
Keywords: calcium uniporter; micu1; micu1 occlusion; mitochondrial calcium ... See more keywords
Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi
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DOI: 10.1091/mbc.e19-03-0152
Abstract: We report here that Trypanosoma cruzi, the etiologic agent of Chagas disease, possesses two unique paralogues of the mitochondrial calcium uniporter complex TcMCU subunit that we named TcMCUc and TcMCUd. The predicted structure of the… read more here.
Keywords: calcium uniporter; cell; mitochondrial calcium; trypanosoma cruzi ... See more keywords
The mechanical effects of CRT promoting autophagy via mitochondrial calcium uniporter down‐regulation and mitochondrial dynamics alteration
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DOI: 10.1111/jcmm.14227
Abstract: The mechanism of cardiac resynchronization therapy (CRT) remains unclear. In this study, mitochondria calcium uniporter (MCU), dynamin‐related protein‐1 (DNM1L/Drp1) and their relationship with autophagy in heart failure (HF) and CRT are investigated. Thirteen male beagle's… read more here.
Keywords: calcium uniporter; dnm1l drp1; crt; mechanical effects ... See more keywords
Cryo-EM structure of a mitochondrial calcium uniporter
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DOI: 10.1126/science.aar4056
Abstract: A channel for calcium Maintaining the correct balance of calcium concentrations between the cytosol and the mitochondria is essential for cellular physiology. A calcium-selective channel called the mitochondrial calcium uniporter (MCU) mediates calcium entry into… read more here.
Keywords: calcium uniporter; mcu; physiology; mitochondrial calcium ... See more keywords
The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
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DOI: 10.3390/ijms23126667
Abstract: Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca2+ is not only an important messenger for cell proliferation, but… read more here.
Keywords: calcium uniporter; ca2; tumor cells; mitochondrial calcium ... See more keywords