Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c02930
Abstract: The mitochondrial calcium uniporter (MCU) is a transmembrane protein that resides on the inner membrane of the mitochondria and mediates calcium uptake into this organelle. Given the critical role of mitochondrial calcium trafficking in cellular… read more here.
Keywords: spectroscopy; mcu inhibitor; ru265; calcium uptake ... See more keywords
MCUB and mitochondrial calcium uptake – modeling, function, and therapeutic potential
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1732926
Abstract: Mitochondria are essential cellular organelles for energy production and calcium (Ca2+) critically regulates their function. At physiological levels, mitochondrial calcium (mCa2+) uptake stimulates... read more here.
Keywords: calcium uptake; mitochondrial calcium; uptake modeling; calcium ... See more keywords
Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand
Sign Up to like & getrecommendations! Published in 2017 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000002448
Abstract: Objectives: To investigate the relationship between prognosis, changes in mitochondrial calcium uptake, and bioenergetic status in the heart during sepsis. Design: In vivo and ex vivo controlled experimental studies. Setting: University research laboratory. Subjects: Male… read more here.
Keywords: sepsis; microscopy; calcium uptake; mitochondrial calcium ... See more keywords
Abstract 16592: Excessive MCU-Mediated Mitochondrial Calcium Uptake During Chronic Stress Impairs Cardiac Contractility
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16592
Abstract: Calcium (Ca 2+ ) uptake into the mitochondrial matrix occurs via the mitochondrial Ca 2+ uniporter channel (mtCU) and tunes mitochondrial metabolism to meet acute changes in cellular ATP demand. However, the role of mtCU-dependent… read more here.
Keywords: uptake; mcu mice; mcu; calcium uptake ... See more keywords
Effects of MICU1-Mediated Mitochondrial Calcium Uptake on Energy Metabolism and Quality of Vitrified-Thawed Mouse Metaphase II Oocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158629
Abstract: Background: Oocyte vitrification has been widely used in the treatment of infertility and fertility preservation. However, vitrification-induced mitochondrial damage adversely affects oocyte development. Several studies have reported that mitochondrial calcium uptake protein 1 (MICU1) regulates… read more here.
Keywords: calcium; vitrification; micu1; calcium uptake ... See more keywords