Membrane extraction by calmodulin underpins the disparate signalling of RalA and RalB
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200011
Abstract: Both RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane‐associated state, only RalA can be extracted from the… read more here.
Keywords: rala ralb; rala; membrane; disparate signalling ... See more keywords
Molecular modeling and chemometric analysis of osteoporosis calmodulin‐TRPV1 binding affinity by statistically characterizing complex interactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemometrics"
DOI: 10.1002/cem.2989
Abstract: The intermolecular interaction among the calcium sensor, calmodulin (CaM), and the C‐terminal domain of its cognate partner, transient receptor potential vanilloid 1 (TRPV1), plays a potential role in bone absorption and loss, which has been… read more here.
Keywords: trpv1; modeling chemometric; molecular modeling; trpv1 binding ... See more keywords
Structural dynamics of the complex of calmodulin with a minimal functional construct of eukaryotic elongation factor 2 kinase and the role of Thr348 autophosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4087
Abstract: The calmodulin (CaM) activated α‐kinase, eukaryotic elongation factor 2 kinase (eEF‐2K), plays a central role in regulating translational elongation by phosphorylating eukaryotic elongation factor 2 (eEF‐2), thereby reducing its ability to associate with the ribosome… read more here.
Keywords: cam; eukaryotic elongation; calmodulin; elongation ... See more keywords
Endothelial regulation of calmodulin expression and eNOS-calmodulin interaction in vascular smooth muscle.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-022-04391-7
Abstract: Calmodulin (CaM) is a Ca2+ sensor protein that is required for numerous vascular smooth muscle cell (VSMC) functions. Since CaM is not expressed enough for its many target proteins, factors that modulate its expression and… read more here.
Keywords: cam; ecs; expression; vascular smooth ... See more keywords
High affinity binding of amyloid β-peptide to calmodulin: Structural and functional implications.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.151
Abstract: Amyloid β-peptides (Aβ) are a major hallmark of Alzheimer's disease (AD) and their neurotoxicity develop with cytosolic calcium dysregulation. On the other hand, calmodulin (CaM), a protein which plays a major multifunctional role in neuronal… read more here.
Keywords: cam; affinity binding; high affinity; affinity ... See more keywords
Molecular characterization of calmodulin from Sarcoptes scabiei.
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology international"
DOI: 10.1016/j.parint.2016.11.005
Abstract: Scabies, caused by the mite Sarcoptes scabiei, is a highly contagious parasitic disease that affects millions of people and other mammals worldwide. Calmodulin (CaM) is an important calcium sensor that participates in various critical physiological… read more here.
Keywords: molecular characterization; rsscam; calmodulin; sscam ... See more keywords
Non-Canonical Interaction between Calmodulin and Calcineurin Contributes to the Differential Regulation of Plant-Derived Calmodulins on Calcineurin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00873
Abstract: Calmodulin (CaM) serves as an important Ca2+ signaling hub that regulates many protein signaling pathways. Recently, it was demonstrated that plant CaM homologues can regulate mammalian targets, often in a manner that opposes the impact… read more here.
Keywords: cam; plant; plant derived; calmodulin ... See more keywords
Calmodulin's Interdomain Linker Is Optimized for Dynamics Signal Transmission and Calcium Binding
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00587
Abstract: Linkers are ubiquitous in multidomain proteins. These linkers are integral to protein functions, and accumulating evidence suggests that the linkers' versatile roles are encoded in their sequences. However, a molecular picture of how amino acid… read more here.
Keywords: type linker; linker; wild type; ca2 ... See more keywords
Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06611
Abstract: Paramagnetic NMR constraints are very useful to study protein interdomain motion, but their interpretation is not always straightforward. On the example of the particularly flexible complex Calmodulin/Munc13-1, we present a new approach to characterize this… read more here.
Keywords: flexible complex; complex calmodulin; calmodulin munc13; paramagnetic nmr ... See more keywords
LsHSP70 is induced by high temperature to interact with calmodulin, leading to higher bolting resistance in lettuce
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-72443-3
Abstract: High temperatures have significant impacts on heat-tolerant bolting in lettuce. In this study, it was found that high temperatures could facilitate the accumulation of GA in lettuce to induce bolting, with higher expression levels of… read more here.
Keywords: high temperatures; lettuce; resistance lettuce; high temperature ... See more keywords
Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300309120
Abstract: Calmodulin (CaM) regulates many ion channels to control calcium entry into cells, and mutations that alter this interaction are linked to fatal diseases. The structural basis of CaM regulation remains largely unexplored. In retinal photoreceptors,… read more here.
Keywords: structural basis; cam; cyclic nucleotide; nucleotide gated ... See more keywords