Early time‐restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23420
Abstract: This trial aimed to evaluate the acceptability and efficacy of early time‐restricted eating plus daily caloric restriction (E‐TRE+DCR) compared with DCR alone within a behavioral weight‐loss intervention. read more here.
Keywords: caloric restriction; trial; time restricted; restricted eating ... See more keywords
Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23660
Abstract: This study compared intermittent fasting and protein pacing (IF‐P) versus a heart‐healthy caloric restriction (CR) diet, matched for energy intake and physical activity energy expenditure, on body weight, total and visceral fat mass, and cardiometabolic… read more here.
Keywords: caloric restriction; visceral fat; fasting protein; intermittent fasting ... See more keywords
Energy and caloric restriction, and fasting and cancer: a narrative review
Sign Up to like & getrecommendations! Published in 2020 at "Supportive Care in Cancer"
DOI: 10.1007/s00520-020-05879-y
Abstract: Dietary interventions have a significant impact on body metabolism. The sensitivity of cancer cells to nutrient and energy deficiency is an evolving characteristic of cancer biology. Preclinical studies provided robust evidence that energy and caloric… read more here.
Keywords: energy caloric; energy; caloric restriction; restriction fasting ... See more keywords
Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0611-8
Abstract: Caloric restriction (CR) has anti-epileptic effects in different animal models, at least partially due to inhibition of the mechanistic or mammalian target of rapamycin (mTOR) signaling pathway. Adenosine monophosphate-activated protein kinase (AMPK) inhibits mTOR cascade… read more here.
Keywords: anti epileptic; caloric restriction; metformin plus; inhibition ... See more keywords
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-021-00509-9
Abstract: Intermediate endpoints are needed to evaluate the effect of interventions targeting the biology of aging in clinical trials. A working group identified five blood-based biomarkers that may serve such a purpose as an integrated index.… read more here.
Keywords: biomarker index; index; exercise; caloric restriction ... See more keywords
Recent advances in the field of caloric restriction mimetics and anti-aging molecules
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101240
Abstract: Caloric restriction (CR) mimetics are molecules that produce beneficial effects on health and longevity in model organisms and humans, without the challenges of maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and… read more here.
Keywords: mimetics anti; aging molecules; restriction mimetics; caloric restriction ... See more keywords
Inhibition of GIP signaling extends lifespan without caloric restriction.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.036
Abstract: AIMS/INTRODUCTION Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes… read more here.
Keywords: inhibition gip; caloric restriction; gip signaling; gip ... See more keywords
The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trials.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2020.06.029
Abstract: BACKGROUND & AIMS Preclinical evidence suggests that caloric restriction is an effective therapy for a number of cardiovascular insults. Whether caloric restriction has cardio-protective effects in humans is not well understood. The aim was to… read more here.
Keywords: restriction; review meta; caloric restriction; effect ... See more keywords
Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.01.018
Abstract: The increase in life expectancy has boosted the incidence of age-related pathologies beyond social and economic sustainability. Consequently, there is an urgent need for interventions that revert or at least prevent the pathogenic age-associated deterioration.… read more here.
Keywords: age; restriction mimetics; caloric restriction; mimetics age ... See more keywords
Lifelong dietary intervention does not affect hematopoietic stem cell function.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental hematology"
DOI: 10.1016/j.exphem.2017.06.002
Abstract: Hematopoietic stem cells (HSCs) undergo a profound functional decline during normal aging. Because caloric or dietary restriction has been shown to delay multiple aspects of the aging process in many species, we explored the consequences… read more here.
Keywords: lifelong dietary; caloric restriction; hematopoietic stem; function ... See more keywords
Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.10.058
Abstract: BACKGROUND Sirtuin 1 (Sirt1) plays an important role in vascular biology, and influences aspects of age-dependent atherosclerosis. In animals, the sirtuin system is strongly influenced by resveratrol and caloric restriction, but its expression in humans… read more here.
Keywords: restriction; serum concentrations; restriction resveratrol; caloric restriction ... See more keywords