Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques.
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DOI: 10.1007/s11357-020-00259-0
Abstract: As human lifespan increases and the population ages, diseases of aging such as Alzheimer's disease (AD) are a major cause for concern. Although calorie restriction (CR) as an intervention has been shown to increase healthspan… read more here.
Keywords: calorie restriction; rhesus; increase; density ... See more keywords
Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics.
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DOI: 10.1007/s11357-020-00298-7
Abstract: Calorie restriction mimetics encompass a growing research field directed toward developing treatments that mimic the anti-aging effects of long-term calorie restriction without requiring a change in eating habits. A wide range of approaches have been… read more here.
Keywords: restriction; calorie restriction; restriction mimetics; strategy ... See more keywords
Calorie restriction and its impact on gut microbial composition and global metabolism
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DOI: 10.1007/s11684-018-0670-8
Abstract: Calorie restriction (CR) is a dietary regimen that reduces calorie intake without incurring malnutrition or a reduction in essential nutrients. It has long been recognized as a natural strategy for promoting health, extending longevity, and… read more here.
Keywords: composition global; calorie restriction; metabolism; global metabolism ... See more keywords
Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy
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DOI: 10.1007/s13105-021-00863-4
Abstract: Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential consumption of glucose over fatty acids to support the high energetic demand. Calorie restriction… read more here.
Keywords: restriction; induced cardiac; cardiac hypertrophy; calorie restriction ... See more keywords
Is there any role of intermittent fasting in the prevention and improving clinical outcomes of COVID-19?: intersection between inflammation, mTOR pathway, autophagy and calorie restriction
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DOI: 10.1007/s13337-021-00703-5
Abstract: The coronavirus disease 2019 (COVID-19) pandemic is provoking a global public health crisis. Even though the academic world is intensively pursuing new therapies, there is still no “game changer” in the management of COVID 19.… read more here.
Keywords: mtor pathway; calorie restriction; clinical outcomes; mtor ... See more keywords
Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity
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DOI: 10.1016/j.appet.2019.104397
Abstract: Calorie restriction (CR) enhances longevity in humans who are normal weight, overweight and obese. While dietary regimens can change self-efficacy, eating behaviors, and food cravings in individuals with obesity, the responses of these measures to… read more here.
Keywords: calorie restriction; efficacy eating; self efficacy; group ... See more keywords
Calorie restriction in humans: An update
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DOI: 10.1016/j.arr.2016.08.005
Abstract: Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate nutrition, has been shown to extend healthspan and lifespan in rodent and primate models. Accumulating data from observational and randomized clinical trials… read more here.
Keywords: intervention; restriction; restriction humans; calorie restriction ... See more keywords
Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice.
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DOI: 10.1016/j.bbrc.2020.01.109
Abstract: Calorie restriction (CR) ameliorates various diseases including cardiovascular disease. However, its protection and underlying mechanisms against atherosclerosis remain un-fully elucidated. In this study, we fed apoE deficient (apoE-/-) mice in Control group a high-fat diet… read more here.
Keywords: calorie restriction; atherosclerosis apoe; mice; apoe deficient ... See more keywords
Beyond calorie restriction: aging as a biological target for nutrient therapies.
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DOI: 10.1016/j.copbio.2020.11.008
Abstract: Arguably, the most important discovery in the biology of aging to date was that simply reducing food intake extended life and improved many aspects of health in a diversity of animal species. The conventional wisdom… read more here.
Keywords: restriction; calorie restriction; aging biological; restriction aging ... See more keywords
Modified alternate-day fasting vs. calorie restriction in the treatment of patients with metabolic syndrome: A randomized clinical trial.
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DOI: 10.1016/j.ctim.2019.08.021
Abstract: OBJECTIVE The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome. DESIGN This randomized clinical trial was conducted on 70… read more here.
Keywords: modified alternate; calorie restriction; alternate day; day fasting ... See more keywords
Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice.
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DOI: 10.1016/j.kint.2018.04.025
Abstract: It is unclear whether long-term sodium-glucose cotransporter 2 (SGLT2) inhibition such as that during the treatment of diabetes has deleterious effects on the kidney. Therefore, we first sought to determine whether abnormal glucose metabolism occurs… read more here.
Keywords: calorie restriction; inhibition; glucose metabolism; diabetic mice ... See more keywords