Influence of modified atmosphere packaging on protein oxidation, calpain activation and desmin degradation of beef muscles.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8316
Abstract: BACKGROUND Protein oxidation is widespread in biochemical systems. The objective of the study was to investigate the differences in protein oxidation, μ-calpain activity, desmin proteolysis and protein solubility of beef psoas major (PM) and semi-membranosus… read more here.
Keywords: protein oxidation; beef; calpain; oxidation ... See more keywords
CalCleaveMKL: a Tool for Calpain Cleavage Prediction.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8988-1_11
Abstract: Calpain, an intracellular Ca2+-dependent cysteine protease, is known to play a role in a wide range of metabolic pathways through limited proteolysis of its substrates. However, only a limited number of these substrates are currently… read more here.
Keywords: tool calpain; calpain; cleavage; calcleavemkl tool ... See more keywords
Identification of Calpain-Activated Protein Functions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8988-1_12
Abstract: As opposed to proteasome-mediated proteolysis that leads to protein degradation, calpain proteases carry out limited proteolytic cleavages of their substrates. The cleavage of some substrates can produce active fragments that perform functions that are different… read more here.
Keywords: identification calpain; calpain; biology; calpain cleavage ... See more keywords
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0726-1
Abstract: We and others have reported that calpain-1 was increased in myocardial mitochondria from various animal models of heart disease. This study investigated whether constitutive up-regulation of calpain-1 restricted to mitochondria induced myocardial injury and heart… read more here.
Keywords: calpain; heart; mitochondrial superoxide; heart failure ... See more keywords
Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic brain disease"
DOI: 10.1007/s11011-021-00755-y
Abstract: Some mechanisms of neuronal degeneration in endotoxinemia are already well described, but need to be detailed. In this study, we tested the effect of a single intraperitoneal injection of a LPS sub-septic dose (1 mg/kg of… read more here.
Keywords: calpain; hippocampus; endotoxin; single intraperitoneal ... See more keywords
Cell-Permeable Calpain Inhibitor SJA6017 Provides Functional Protection to Spinal Motoneurons Exposed to MPP+
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity Research"
DOI: 10.1007/s12640-020-00264-3
Abstract: Extra-nigral central nervous system sites have been found to be affected in Parkinson’s disease (PD). In addition to substantia nigra, degeneration of spinal cord motor neurons may play a role in the motor symptoms of… read more here.
Keywords: mpp; calpain inhibitor; calpain; spinal motoneurons ... See more keywords
Acidification induces OGR1/Ca2+/calpain signaling in gingival fibroblasts.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.131
Abstract: Gingivitis, the mildest form of periodontitis, is generally considered a consequence of prolonged exposure of the gingiva to periodontal pathogens. On the other hand, several epidemiologic reports have suggested that other etiologic factors such as… read more here.
Keywords: calpain; acidification; acidification induces; gingival fibroblasts ... See more keywords
Presence of calpain-5 in mitochondria.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.144
Abstract: Calpains are Ca2+-dependent cysteine proteases that are widely distributed in animal tissues and modulate a variety of cellular processes. There are 15 members of the calpain family in mammals. In animal cells, there are three… read more here.
Keywords: calpain; photoreceptor cells; microscopy; calpain mitochondria ... See more keywords
Calpain inhibitor alleviates permanent hearing loss induced by intense noise by preventing disruption of gap junction‐mediated intercellular communication in the cochlear spiral ligament
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.03.058
Abstract: Abstract Our previous studies demonstrated that intense noise‐induced hearing loss might be at least in part due to an oxidative stress‐induced decrease in the level of gap junction‐composing protein connexins in the spiral ligament (SL)… read more here.
Keywords: hearing loss; calpain; noise; intense noise ... See more keywords
Verdiperstat attenuates acute lung injury by modulating MPO/μ-calpain/β-catenin signaling.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174940
Abstract: Verdiperstat, a myeloperoxidase (MPO) inhibitor, is a well-known drug used for the treatment of multisystem atrophy. However, its therapeutic effect on acute lung injury (ALI) remains to be elucidated. In this study, the effect of… read more here.
Keywords: catenin; acute lung; verdiperstat; injury ... See more keywords
Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113315
Abstract: Parkinson's disease (PD), a debilitating progressive degenerative movement disorder associated with loss of dopaminergic (DA) neurons in the substantia nigra (SN), afflicts approximately one million people in the U.S., including a significant number of Veterans.… read more here.
Keywords: calpain; cells rodent; disease; rodent models ... See more keywords