The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration
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DOI: 10.1016/j.tins.2021.07.003
Abstract: Calpains are evolutionarily conserved and widely expressed Ca2+-activated cysteine proteases that act at neutral pH. The activity of calpains is tightly regulated, given that their abnormal activation can have deleterious effects leading to promiscuous cleavage… read more here.
Keywords: calcium dependent; calpain neuronal; neurodegeneration; protease calpain ... See more keywords
Regulatory role of calpain in neuronal death
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DOI: 10.4103/1673-5374.228762
Abstract: Calpains are a group of calcium-dependent proteases that are over activated by increased intracellular calcium levels under pathological conditions. A wide range of substrates that regulate necrotic, apoptotic and autophagic pathways are affected by calpain.… read more here.
Keywords: death; neuronal death; calpain neuronal; role ... See more keywords