Mayo CALR mutation type classification guide using alpha helix propensity
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25065
Abstract: To the Editor: Myeloproliferative neoplasms (MPN) constitute one of the major categories of myeloid neoplasms, according to the World Health Organization (WHO) classification system. Included under the 2016 WHO MPN category are polycythemia vera (PV),… read more here.
Keywords: classification; pmf; calr; type ... See more keywords
A simple and low-cost electrochemical immunosensor for ultrasensitive determination of calreticulin biomarker in human serum.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200390
Abstract: An early on time detection of breast cancer significantly affects the treatment process and outcome. Herein, a new label-free impedimetric biosensor is developed to determine the lowest change in the level of calreticulin (CALR), which… read more here.
Keywords: calreticulin; immunosensor; biomarker; calr ... See more keywords
Elevated expression of the EZH2 gene in CALR-mutated patients with primary myelofibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3287-8
Abstract: Primary myelofibrosis (PMF) is one of the BCR/ABL-negative myeloproliferative neoplasms (MPNs), characterized by the diffuse fibrous hyperproliferation, bone marrow osteosclerosis, extramedullary hematopoiesis, and marked splenomegaly. The patients with PMF have an insidious onset, a long… read more here.
Keywords: mutated patients; primary myelofibrosis; calr mutated; expression ezh2 ... See more keywords
A rare CALR variant mutation and a review of CALR in essential thrombocythemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-018-1619-0
Abstract: Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm characterized by megakaryocyte hyperplasia, thrombocytosis, thrombotic and hemorrhagic complications, and potential transformation into myelofibrosis and acute myeloid leukemia. The vast majority of cases are driven by a… read more here.
Keywords: review; rare calr; calr; essential thrombocythemia ... See more keywords
Estimation of diagnosis and prognosis in ET by assessment of CALR and JAK2V617F mutations and laboratory findings: a meta-analysis
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DOI: 10.1007/s12094-017-1618-1
Abstract: BackgroundEssential thrombocythemia (ET) is a benign disease with slow progress in which thrombosis is a cause of mortality. JAK2V617F and calreticulin (CALR) are the most frequent mutations in this disease. In this systematic review and… read more here.
Keywords: jak2v617f; diagnosis; prognosis; calr ... See more keywords
Lab tests for MPN.
Sign Up to like & getrecommendations! Published in 2022 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2021.02.010
Abstract: Molecular laboratory investigations for myeloproliferative neoplasm (MPN) can ideally be divided into two distincts groups, those for the detection of the BCR-ABL rearrangement (suspect of chronic myeloid leukemia) and those for the variants determination of… read more here.
Keywords: biology; calr; bcr abl; test ... See more keywords
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.
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DOI: 10.1016/j.leukres.2017.12.005
Abstract: BACKGROUND Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the clinical phenotype of MPN patients… read more here.
Keywords: philadelphia negative; negative myeloproliferative; calr; calr mutations ... See more keywords
Prevalence of CALR mutations in splanchnic vein thrombosis: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.05.007
Abstract: BACKGROUND The prevalence of calreticulin (CALR) mutations in splanchnic vein thrombosis (SVT) varies among studies. The role of routine screening for CALR mutations in SVT patients remains a debate. AIM To synthesize the prevalence of… read more here.
Keywords: jak2v617f mutation; prevalence; calr; calr mutations ... See more keywords
Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib
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DOI: 10.1038/leu.2016.308
Abstract: Mutations of calreticulin (CALR) are detected in 25–30% of patients with essential thrombocythemia (ET) or primary myelofibrosis and cause frameshifts that result in proteins with a novel C-terminal. We demonstrate that CALR mutations activated signal… read more here.
Keywords: inhibitor ruxolitinib; jak inhibitor; mice; calr ... See more keywords
AKT activation is a feature of CALR mutant myeloproliferative neoplasms
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DOI: 10.1038/s41375-018-0224-8
Abstract: Among the driver mutations in the MPNs, the mechanism by which CALR mutations activate JAK/STAT signaling is unique in that the novel C-terminus of CALR mutant proteins binds directly to MPL leading to constitutive activation… read more here.
Keywords: calr; akt activation; calr mutant;
JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation
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DOI: 10.1038/s41375-018-0295-6
Abstract: Pegylated interferon-α (peg-IFNa) treatment induces molecular responses (MR) in patients with myeloproliferative neoplasms (MPNs), including partial MR (PMR) in 30–40% of patients. Here, we compared the efficacy of IFNa treatment in JAK2V617F- vs. calreticulin (CALR)-mutated… read more here.
Keywords: jak2v617f; jak1 stat1; molecular responses; calr mutated ... See more keywords