JAK2V617F, CALR, and MPL Mutations and Bone Marrow Histology in Patients with Essential Thrombocythaemia
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DOI: 10.1159/000493970
Abstract: Introduction: Mutations in the JAK2, CALR, and MPL genes have been shown to have prognostic value in essential thrombocythaemia (ET), but no clear association with morphological changes has been reported so far. We investigated the… read more here.
Keywords: calr mpl; cellularity; number; essential thrombocythaemia ... See more keywords
Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures
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DOI: 10.1182/blood-2025-3815
Abstract: Background: The canonical driver mutations in JAK2, CALR, and MPL are typically regarded as mutually exclusive in myeloproliferative neoplasms (MPNs). However, co-occurrence is increasingly recognized, raising questions about their clinical and clonal implications. Such co-mutations… read more here.
Keywords: jak2 calr; calr; mpl; calr mpl ... See more keywords
Primary myelofibrosis with concurrent CALR and MPL mutations: A case report
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DOI: 10.12998/wjcc.v8.i22.5618
Abstract: BACKGROUND Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by recurrent mutations in the JAK2, CALR, and MPL genes. The CALR and MPL co-mutation is very rare. To our knowledge, no more than five… read more here.
Keywords: mpl mutations; calr mpl; primary myelofibrosis; case ... See more keywords