Mayo CALR mutation type classification guide using alpha helix propensity
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25065
Abstract: To the Editor: Myeloproliferative neoplasms (MPN) constitute one of the major categories of myeloid neoplasms, according to the World Health Organization (WHO) classification system. Included under the 2016 WHO MPN category are polycythemia vera (PV),… read more here.
Keywords: classification; pmf; calr; type ... See more keywords
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.12.005
Abstract: BACKGROUND Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the clinical phenotype of MPN patients… read more here.
Keywords: philadelphia negative; negative myeloproliferative; calr; calr mutations ... See more keywords
Prevalence of CALR mutations in splanchnic vein thrombosis: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis research"
DOI: 10.1016/j.thromres.2018.05.007
Abstract: BACKGROUND The prevalence of calreticulin (CALR) mutations in splanchnic vein thrombosis (SVT) varies among studies. The role of routine screening for CALR mutations in SVT patients remains a debate. AIM To synthesize the prevalence of… read more here.
Keywords: jak2v617f mutation; prevalence; calr; calr mutations ... See more keywords
Impact of interferon on a triple positive polycythemia vera
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0636-0
Abstract: Sir, We read the paper by Julia Czech et al., “JAK2V617F but not CALR mutations confer increased molecular responses to interferonvia JAK1/STAT1 activation” [1], with great interest. This paper reports that JAK2V617Fmutated patients with myeloproliferative… read more here.
Keywords: week; impact interferon; polycythemia vera; polycythemia ... See more keywords
Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Blood Cancer Journal"
DOI: 10.1038/s41408-019-0202-z
Abstract: Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce… read more here.
Keywords: mpl; human calr; mild thrombocytosis; mice ... See more keywords
Absence of CALR Mutations in Idiopathic Erythrocytosis Patients with Low Serum Erythropoietin Levels
Sign Up to like & getrecommendations! Published in 2018 at "Acta Haematologica"
DOI: 10.1159/000489006
Abstract: a Clinical Haematology, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, UK; b Ecole Pratique des Hautes Etudes (EPHE), PSL Research University, Paris, France; c INSERM U892, CNRS 6299, Université de Nantes, Nantes,… read more here.
Keywords: erythrocytosis patients; belfast; absence calr; calr mutations ... See more keywords
Calreticulin Ins5 and Del52 Mutations Impair Unfolded Protein and Oxidative Stress Responses in Hematopoietic Cells
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-112550
Abstract: Somatic mutations of calreticulin (CALR) have been described in approximately 30-40% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protein folding and… read more here.
Keywords: calr mutants; unfolded protein; stress; calr ... See more keywords