Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms.
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DOI: 10.1182/blood.2022016846
Abstract: Mutant calreticulin (CALR) proteins resulting from a -1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino-acid sequence and drive the development of myeloproliferative neoplasms (MPNs). Mutant CALRs were shown to interact… read more here.
Keywords: cell; calr; mutant calr; calr proteins ... See more keywords