Hematological relevance of JAK2 V617F and calreticulin mutations in Tunisian patients with essential thrombocythemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24522
Abstract: The genetic investigation of essential thrombocythemia(ET) has highlighted the presence of driver mutations in ET. Janus kinase JAK2V617F and calreticulin(CALR) mutations are the most frequent driver mutations and have significantly improved the molecular diagnosis of… read more here.
Keywords: essential thrombocythemia; calreticulin; v617f calreticulin; hematological relevance ... See more keywords
A simple and low-cost electrochemical immunosensor for ultrasensitive determination of calreticulin biomarker in human serum.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200390
Abstract: An early on time detection of breast cancer significantly affects the treatment process and outcome. Herein, a new label-free impedimetric biosensor is developed to determine the lowest change in the level of calreticulin (CALR), which… read more here.
Keywords: calreticulin; immunosensor; biomarker; calr ... See more keywords
Calnexin/Calreticulin and Assays Related to N-Glycoprotein Folding In Vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0430-4_29
Abstract: Calnexin (CNX) and calreticulin (CRT) are ER-resident lectin-like molecular chaperones involved in the quality control of secretory or membrane glycoproteins. They can exert molecular chaperone functions via specific binding to the early processing intermediates of… read more here.
Keywords: calnexin calreticulin; calnexin; calreticulin; cnx crt ... See more keywords
Monitoring thermal and chemical unfolding of Brugia malayi calreticulin using fluorescence and Circular Dichroism spectroscopy.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.04.053
Abstract: Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible for prevention of host classical complement pathway activation via its interaction with first… read more here.
Keywords: bmcrt; brugia malayi; calreticulin; spectroscopy ... See more keywords
Phylogenetic analysis of plant calreticulin homologs.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular phylogenetics and evolution"
DOI: 10.1016/j.ympev.2019.01.014
Abstract: Calreticulin (CRT) is an multifunctional resident endoplasmic reticulum (ER) luminal protein implicated in regulating a variety of cellular processes, including Ca2+ storage/mobilization and protein folding. These multiple functions may be carried out by different CRT… read more here.
Keywords: calreticulin; phylogenetic analysis; plant; crt genes ... See more keywords
Dissecting physical structure of calreticulin, an intrinsically disordered Ca2+-buffering chaperone from endoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1330224
Abstract: Calreticulin (CALR) is a Ca2+ binding multifunctional protein that mostly resides in the endoplasmic reticulum (ER) and plays a number of important roles in various physiological and pathological processes. Although the major functions ascribed to… read more here.
Keywords: physical structure; dissecting physical; calreticulin; endoplasmic reticulum ... See more keywords
Calreticulin Expression Controls Cellular Redox, Stemness, and Radiosensitivity to Function as a Novel Adjuvant for Radiotherapy in Neuroblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/8753309
Abstract: Radiotherapy (RT) is currently only used in children with high-risk neuroblastoma (NB) due to concerns of long-term side effects as well as lack of effective adjuvant. Calreticulin (CALR) has served distinct physiological roles in cancer… read more here.
Keywords: calreticulin; calr expression; radiotherapy; stemness ... See more keywords
Abstract 3963: Mass spectrometry reveals a downregulation of calreticulin after neoadjuvant chemotherapy in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3963
Abstract: Introduction: Pancreatic ductal adenocarcinomas are one of the deadliest cancer types with limited response to current therapies. Thus, this study examined changes in the proteome of epithelial cells in pancreatic cancer after neoadjuvant chemotherapy with… read more here.
Keywords: neoadjuvant chemotherapy; calreticulin; pancreatic cancer; mass spectrometry ... See more keywords
Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients withmyeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019001103
Abstract: About one fourth of patients with essential thrombocythemia or primary myelofibrosis carry a somatic mutation of CALR, the gene encoding for calreticulin. A 52-bp deletion (Type I mutation) and a 5-bp insertion (Type II mutation)… read more here.
Keywords: mutant calreticulin; calreticulin; megakaryocytes patients; myeloproliferative neoplasms ... See more keywords
Brain Cells Release Calreticulin That Attracts and Activates Microglia, and Inhibits Amyloid Beta Aggregation and Neurotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859686
Abstract: Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ). We investigated whether… read more here.
Keywords: calreticulin; amyloid beta; brain cells; release calreticulin ... See more keywords
Yeast Secretes High Amounts of Human Calreticulin without Cellular Stress
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44050122
Abstract: The ER chaperone calreticulin (CALR) also has extracellular functions and can exit the mammalian cell in response to various factors, although the mechanism by which this takes place is unknown. The yeast Saccharomyces cerevisiae efficiently… read more here.
Keywords: calreticulin; calr; yeast secretes; yeast ... See more keywords