The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.151893
Abstract: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains unknown is the cellular source… read more here.
Keywords: purkinje cells; calsequestrin; cpvt; ventricular arrhythmia ... See more keywords
Ablation of Calsequestrin-1, Ca2+ unbalance, and susceptibility to heat stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1033300
Abstract: Introduction: Ca2+ levels in adult skeletal muscle fibers are mainly controlled by excitation-contraction (EC) coupling, a mechanism that translates action potentials in release of Ca2+ from the sarcoplasmic reticulum (SR) release channels, i.e. the ryanodine… read more here.
Keywords: heat stroke; casq1 null; null mice; ca2 ... See more keywords