Calycosin represses AIM2 inflammasome‐mediated inflammation and pyroptosis to attenuate monosodium urate‐induced gouty arthritis through NF‐κB and p62‐Keap1 pathways
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21985
Abstract: Gouty arthritis is an inflammatory disease induced by monosodium urate (MSU), and is closely related to the activation of inflammasomes. Calycosin plays an anti‐inflammatory role in arthritis. This study explored the mechanism of Calycosin in… read more here.
Keywords: calycosin; pyroptosis; gouty arthritis; msu induced ... See more keywords
In vitro and in vivo Study on Glioma Treatment Enhancement by Combining Temozolomide with Calycosin and Formononetin.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.01.023
Abstract: Abstract Ethnopharmacological relevance Astragalina alpestris is a traditional Chinese herbal medicine with anti-inflammatory, anti-immune, anti-tumor and other pharmacological effects. Calycosin and formononetin (FMN) are two natural compounds isolated from astragalus. It has been shown that… read more here.
Keywords: medicine; glioma; vivo; calycosin ... See more keywords
Preparative Isolation and Purification of Calycosin and Formononetin from Astragali Radix using Hydrolytic Extraction Combined with High Speed Countercurrent Chromatography.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmab021
Abstract: Calycosin and formononetin were efficiently extracted from Astragali Radix and purified by high-speed countercurrent chromatography. Calycosin and formononetin could be hydrolyzed from calycosin-7-glucoside and ononin, respectively. The best extraction conditions were realized by single factor… read more here.
Keywords: extraction; astragali radix; calycosin; calycosin formononetin ... See more keywords
Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review
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DOI: 10.1097/md.0000000000038023
Abstract: Cancer remains a significant challenge in the field of oncology, with the search for novel and effective treatments ongoing. Calycosin (CA), a phytoestrogen derived from traditional Chinese medicine, has garnered attention as a promising candidate.… read more here.
Keywords: cancer; multi targeting; calycosin; medicine ... See more keywords
Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down‐regulating HIF‐1α
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13763
Abstract: Calycosin, a bioactive component derived from Astragali Radix (AR; Huang Qi), has been shown to have an effect of anti‐allergic dermatitis with unknown mechanism. This study aims to investigate the mechanism of calycosin related to… read more here.
Keywords: hif; allergic contact; calycosin; tight junctions ... See more keywords
Inhibition effect of phytoestrogen calycosin on TGF-β1-induced hepatic stellate cell activation, proliferation, and migration via estrogen receptor β.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2018-0474
Abstract: The present study was designed to investigate the effects of calycosin on hepatic stellate cell (HSC) function and to explore whether the drug exerts its effect through the estrogen receptor. HSC proliferation and migration were… read more here.
Keywords: calycosin; proliferation; effect; migration ... See more keywords
Calycosin Ameliorates Neuroinflammation via TLR4-Mediated Signal Following Cerebral Ischemia/Reperfusion Injury in vivo and in vitro
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DOI: 10.2147/jir.s480262
Abstract: Background Cerebral ischemia-reperfusion injury (CIRI) is a key pathophysiological process that leads to stroke mortality, with TLR4-mediated inflammation playing a crucial role. Our previous research highlighted the neuroprotective effects of the phytoestrogen calycosin on CIRI,… read more here.
Keywords: ischemia reperfusion; reperfusion; cerebral ischemia; tlr4 ... See more keywords
Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1056687
Abstract: Calycosin, one of small molecules derived from astragalus, has anti-tumor effects in various tumors. However, the effects of calycosin on papillary thyroid cancer (PTC) remain unclear. This study aimed to explore the anti-tumor ability of… read more here.
Keywords: apoptosis; calycosin; ampk mtor; sestrin2 ... See more keywords
Calycosin induces apoptosis in osteosarcoma cell line via ERβ-mediated PI3K/Akt signaling pathways
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DOI: 10.3892/mmr.2020.11039
Abstract: Previous studies have shown that calycosin, a natural phytoestrogen which is structurally similar to estrogen, inhibits proliferation and induces apoptosis in estrogen-dependent cancer types via the estrogen receptor (ER)β-induced inhibition of PI3K/Akt. Therefore, the aims… read more here.
Keywords: signaling pathways; calycosin; pi3k akt; induces apoptosis ... See more keywords
Calycosin attenuates neuronal ferroptosis in Alzheimer's disease mice by activating the Nrf2/HO-1 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "General physiology and biophysics"
DOI: 10.4149/gpb_2025021
Abstract: In this study, we investigated the therapeutic potential of calycosin (from Astragalus) in Alzheimer's disease (AD), focusing on ferroptosis modulation. APP/PS1 mice received 40 mg/kg calycosin for 3 months. Cognitive function was assessed via Morris… read more here.
Keywords: alzheimer disease; mice; ferroptosis; calycosin ... See more keywords