Postnatal maturation of glutamate clearance and release kinetics at the rat and mouse calyx of Held synapses
Sign Up to like & getrecommendations! Published in 2021 at "Synapse"
DOI: 10.1002/syn.22215
Abstract: Although calyx of Held synapses undergo dramatic changes around the hearing onset, previous in vivo studies suggest that the calyx synapses undergo further post‐hearing maturation process. While developmental changes over the hearing onset have been… read more here.
Keywords: calyx held; hearing maturation; held synapses; calyx synapses ... See more keywords
Some Subtle Lessons from the Calyx of Held Synapse
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.12.017
Abstract: The calyx of Held is a giant nerve terminal that forms a glutamatergic synapse in the auditory pathway. Due to its large size, it offers a number of advantages for biophysical studies, including voltage-clamp of… read more here.
Keywords: lessons calyx; calyx held; subtle lessons; held synapse ... See more keywords
Vesicular Glutamate Transporter Expression Ensures High-Fidelity Synaptic Transmission at the Calyx of Held Synapses.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108040
Abstract: Recycling of synaptic vesicles (SVs) at presynaptic terminals is required for sustained neurotransmitter release. Although SV endocytosis is a rate-limiting step for synaptic transmission, it is unclear whether the rate of the subsequent SV refilling… read more here.
Keywords: calyx held; transmission; held synapses; synaptic transmission ... See more keywords
Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo4173
Abstract: The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters that are aligned with presynaptic release sites is essential for the high fidelity of synaptic transmission. However, the mechanisms controlling the nanoscale organization of neurotransmitter receptors… read more here.
Keywords: calyx held; synaptic transmission; synaptic strength; ampa receptors ... See more keywords
Developmental shift to mitochondrial respiration for energetic support of sustained transmission during maturation at the calyx of Held.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00333.2021
Abstract: A considerable amount of energy is expended following presynaptic activity to regenerate electrical polarization and maintain efficient release and recycling of neurotransmitter. Mitochondria are the major suppliers of neuronal energy, generating ATP via oxidative phosphorylation.… read more here.
Keywords: mitochondrial respiration; calyx held; energy; transmission ... See more keywords
Physiological Perspectives on Molecular Mechanisms and Regulation of Vesicular Glutamate Transport: Lessons From Calyx of Held Synapses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.811892
Abstract: Accumulation of glutamate, the primary excitatory neurotransmitter in the mammalian central nervous system, into presynaptic synaptic vesicles (SVs) depends upon three vesicular glutamate transporters (VGLUTs). Since VGLUTs are driven by a proton electrochemical gradient across… read more here.
Keywords: calyx held; glutamate; vesicular glutamate; glutamate refilling ... See more keywords