Elucidation of pathological mechanism caused by human disease mutation in CaMKIIβ
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25013
Abstract: Recently, we have identified CaMKIIα and CaMKIIβ mutations in patients with neurodevelopmental disorders by whole exome sequencing study. Most CaMKII mutants have increased phosphorylation of Thr286/287, which induces autonomous activity of CaMKII, using cell culture… read more here.
Keywords: mutation camkii; camkii; pathological mechanism; disease ... See more keywords
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-00834-8
Abstract: Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel remodeling and increased arrhythmia risk. However, the exact signaling mechanism by which diabetic hyperglycemia regulates cardiac K+ channels remains elusive. Here, we show that… read more here.
Keywords: nox2 ros; hyperglycemia regulates; camkii; hyperglycemia ... See more keywords
Up-regulation of Ca2+/CaMKII/CREB signaling in salicylate-induced tinnitus in rats
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3314-z
Abstract: The purpose of the study was to investigate the changes of Ca2+/calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three… read more here.
Keywords: creb; creb signaling; camkii; tinnitus model ... See more keywords
Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.081
Abstract: The subversive role of Calcium sensing receptor (CaSR) in cerebral ischemia and traumatic brain injury has been recently reported. Nevertheless, the role of CaSR in early brain injury (EBI) after subarachnoid hemorrhage (SAH) remains unexplored.… read more here.
Keywords: early brain; camkii; brain injury; brain ... See more keywords
Subunit Exchange and Activation of Human CaMKII Variants
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.207
Abstract: Ca2+-calmodulin dependent protein kinase II (CaMKII) assembles into an oligomeric ring in which the kinase domains are organized around a central hub. Notably, the stimulated activity of CaMKII persists even after the withdrawal of a… read more here.
Keywords: human camkii; camkii; linker; activation ... See more keywords
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.06.001
Abstract: Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ… read more here.
Keywords: protein; myc protein; stabilization myc; camkii ... See more keywords
Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.041
Abstract: CaMKIIα is a central mediator of bidirectional synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). To study how CaMKIIα movement during plasticity is affected by soluble amyloid-β peptide oligomers (Aβ), we used FingR… read more here.
Keywords: ltp; camkii movement; impairment; camkii ... See more keywords
Lactucopicrin potentiates neuritogenesis and neurotrophic effects by regulating Ca2+/CaMKII/ATF1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.12.035
Abstract: ETHNO-PHARMACOLOGICAL RELEVANCE Lactucopicrin is one of constitutes in Cichorium intybus L, which is commonly known as chicory in worldwide. It has been used for traditional usage such as antianalgesics, antidepressants and antihyperglycemics AIM OF STUDY:… read more here.
Keywords: kinase; lactucopicrin potentiates; potentiates neuritogenesis; lactucopicrin ... See more keywords
Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII‐dependent mitochondrion‐mediated apoptosis and MAPK/NF‐&kgr;B signaling
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.11.035
Abstract: Aims: Tilianin, a naturally occurring flavonoid glycoside, possesses versatile biological activities including antioxidant, anti‐inflammatory, energy collecting and anti‐hypoxic effects. Little is known about the mechanisms underlying the effect of tilianin against ischemic injury in neuronal… read more here.
Keywords: mitochondrion mediated; kgr; ischemic injury; camkii ... See more keywords
Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.09.010
Abstract: The abundant synaptic protein CaMKII is necessary for long-term potentiation (LTP) and memory. However, whether CaMKII is required only during initial processes or whether it also mediates memory storage remains unclear. The most direct test… read more here.
Keywords: erasure; memory storage; camkii; test ... See more keywords
John Lisman (1944–2017)
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.11.035
Abstract: On October 20, 2017, John Lisman sadly passed. Being very ill did not hinder his determination, as he was continuing full speed in his research, keeping several collaborations in parallel, writing papers, and giving talks… read more here.
Keywords: lisman; kinase; process; camkii ... See more keywords