Opposing Intermolecular Tuning of Ca2+ Affinity for Calmodulin by Neurogranin and CaMKII Peptides
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DOI: 10.1016/j.bpj.2017.01.020
Abstract: We investigated the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca2+) by integrating coarse-grained models and all-atomistic simulations with nonequilibrium physics. We focused on binding between CaM and two specific… read more here.
Keywords: cam; ca2 affinity; camkii peptide; affinity ... See more keywords