CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2019 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-019-00518-w
Abstract: Purpose of ReviewAge and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its… read more here.
Keywords: metabolism; signaling metabolism; camkk2 signaling; camkk2 ... See more keywords
Systemic Inhibition or Global Deletion of CaMKK2 Protects Against Post-Traumatic Osteoarthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.09.001
Abstract: OBJECTIVE To investigate the role of Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in post-traumatic osteoarthritis (PTOA). METHODS Destabilization of the medial meniscus (DMM) or sham surgeries were performed on 10-week-old male wild-type (WT) and Camkk2-/-… read more here.
Keywords: post traumatic; traumatic osteoarthritis; osteoarthritis; inhibition ... See more keywords
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01658-z
Abstract: Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer progression in part through the modulation of autophagy. However, clinical trials testing autophagy inhibition using chloroquine derivatives in men with castration-resistant prostate cancer (CRPC)… read more here.
Keywords: ampk ulk1; prostate cancer; camkk2; ulk1 signaling ... See more keywords
Abstract 1430: CaMKK2 regulates EGF-dependent activation of oncogenic Akt in ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-1430
Abstract: Background-The canonical PI3K/Akt pathway is hyperactive in a variety of cancers including ovarian cancer (OVCa). Using baculovirus-expressed, FPLC-purified enzymes, we previously demonstrated that Calcium/Calmodulin-dependent CaM Kinase Kinase 2 (CaMKK2) activates the oncogene Akt by direct… read more here.
Keywords: akt; calcium; camkk2; t308 ... See more keywords
Tyrosine Phosphorylation Profiling Revealed the Signaling Network Characteristics of CAMKK2 in Gastric Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.854764
Abstract: Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine protein kinase which functions via the calcium-triggered signaling cascade with CAMK1, CAMK4, and AMPKα as the immediate downstream substrates. CAMKK2 is reported to be overexpressed in… read more here.
Keywords: tyrosine; inhibition; camkk2; gastric cancer ... See more keywords
Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050799
Abstract: Lipotoxicity is an important factor in the development and progression of nonalcoholic steatohepatitis. Excessive accumulation of saturated fatty acids can increase the substrates of the mitochondrial electron transport chain in hepatocytes and cause the generation… read more here.
Keywords: camkk2; ampk pathway; nuclear translocation; camkk2 ampk ... See more keywords
Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054718
Abstract: Calcium/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, its role in osteocytes, the most abundant bone cell type and the master regulator of bone remodeling,… read more here.
Keywords: camkk2; bone; osteocyte; camkk2 regulates ... See more keywords