Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202304940
Abstract: Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, a specific role in T2D pathogenesis… read more here.
Keywords: insulin secretion; tipe1; cell; beta cell ... See more keywords
Spectral imaging of FRET‐based sensors reveals sustained cAMP gradients in three spatial dimensions
Sign Up to like & getrecommendations! Published in 2018 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23572
Abstract: Cyclic AMP is a ubiquitous second messenger that orchestrates a variety of cellular functions over different timescales. The mechanisms underlying specificity within this signaling pathway are still not well understood. Several lines of evidence suggest… read more here.
Keywords: camp; fret; spatial dimensions; spectral imaging ... See more keywords
Roles for H+/K+‐ATPase and zinc transporter 3 in cAMP‐mediated lysosomal acidification in bafilomycin A1‐treated astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23952
Abstract: Vacuolar ATPase (v‐ATPase) is the main proton pump that acidifies vesicles such as lysosomes. Disruption in the lysosomal localization of v‐ATPase leads to lysosomal dysfunction, thus contributing to the pathogenesis of lysosomal storage disorders and… read more here.
Keywords: camp; atpase; mediated lysosomal; camp mediated ... See more keywords
Vinpocetine Alleviates Valproic Acid‐Induced Hepatotoxicity and Neurotoxicity Through Activation of cAMP and PI3K/AKT/CREB Pathway in Rats
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70316
Abstract: Valproic acid (VPA) is a frequently prescribed treatment for many psychiatric disorders, particularly for epilepsy. However, it has been associated with possible side effects including hepatotoxicity and neurotoxicity. The present study investigated the protective effect… read more here.
Keywords: vpa; camp; creb; pi3k akt ... See more keywords
Using participatory culture-specific consultation to support the mental health needs of summer camp staff.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of community psychology"
DOI: 10.1002/jcop.22679
Abstract: Nearly 30% of all U.S. youth attend summer camp each year, making it one of the broadest reaching out-of-school-time interventions in the country. Camp provides a space for seasonal employees, who are often emerging adults,… read more here.
Keywords: camp; consultation; summer camp; summer ... See more keywords
Differential mechanisms of adenosine‐ and ATPγS‐induced microvascular endothelial barrier strengthening
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26419
Abstract: Maintenance of the endothelial cell (EC) barrier is critical to vascular homeostasis and a loss of barrier integrity results in increased vascular permeability. While the mechanisms that govern increased EC permeability have been under intense… read more here.
Keywords: pka activation; barrier; camp; barrier strengthening ... See more keywords
PU.1 and epigenetic signals modulate 1,25‐dihydroxyvitamin D3 and C/EBPα regulation of the human cathelicidin antimicrobial peptide gene in lung epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27702
Abstract: LL‐37, the only known human cathelicidin which is encoded by the human antimicrobial peptide (CAMP) gene, plays a critical role in protection against bacterial infection. We previously demonstrated that cathelicidin is induced by 1,25‐dihydroxyvitamin D3… read more here.
Keywords: cathelicidin; epithelial cells; camp; lung epithelial ... See more keywords
Quantitative phosphoproteomics reveals novel roles of cAMP in plants.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300165
Abstract: 3',5'-cyclic adenosine monophosphate (cAMP) is finally recognized as an essential signaling molecule in plants where cAMP-dependent processes include responses to hormones and environmental stimuli. To better understand the role of 3',5'-cAMP at the systems level,… read more here.
Keywords: quantitative phosphoproteomics; reveals novel; novel roles; camp ... See more keywords
Real-Time Measurements of Intracellular cAMP Gradients Using FRET-Based cAMP Nanorulers.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2245-2_1
Abstract: 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important and ubiquitous second messengers in cells downstream of G protein-coupled receptors (GPCRs). In a single cell, cAMP can exert innumerous specific cell functions in response… read more here.
Keywords: time; camp nanorulers; camp; fret based ... See more keywords
In Vivo cAMP Dynamics in Drosophila Larval Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2245-2_11
Abstract: Cyclic adenosine monophosphate (cAMP) is a universal second messenger that mediates a myriad of cell functions across all kingdoms of life.The ability to monitor intracellular changes of cAMP concentration in living cells using FRET-based biosensors… read more here.
Keywords: camp; drosophila larval; larval neurons; vivo camp ... See more keywords
Fluorescent Translocation Reporters for Sub-plasma Membrane cAMP Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2245-2_20
Abstract: A wide range of fluorescent sensors with different properties have been developed for imaging of cAMP signals in living cells and tissues. Most cAMP reporters have been designed to undergo changes in fluorescence resonance energy… read more here.
Keywords: camp; membrane; plasma membrane; sub plasma ... See more keywords