PDE2 at the crossway between cAMP and cGMP signalling in the heart.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.06.020
Abstract: The cyclic nucleotides cAMP and cGMP are central second messengers in cardiac cells and critical regulators of cardiac physiology as well as pathophysiology. Consequently, subcellular compartmentalization allows for spatiotemporal control of cAMP/cGMP metabolism and subsequent… read more here.
Keywords: heart; camp; cgmp signalling; camp cgmp ... See more keywords
Therapeutic potential of phosphodiesterase inhibitors in the treatment of osteoporosis: scopes for therapeutic repurposing and discovery of new oral osteoanabolic drugs.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174015
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) are ubiquitously expressed enzymes that hydrolyse phosphodiester bond in the second messenger molecules including cAMP and cGMP. A wide range of drugs blocks one or more PDEs thereby preventing the inactivation… read more here.
Keywords: pde inhibitors; treatment; camp cgmp; osteoanabolic drugs ... See more keywords
UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2020.09.001
Abstract: Cyclic 3′,5′-adenosine monophosphate (cAMP) and cyclic 3′,5′-guanosine monophosphate (cGMP) are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese medicine. However, phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in… read more here.
Keywords: potential biomarkers; medicine; camp cgmp; biomarkers yin ... See more keywords
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106108
Abstract: The increase in intracellular calcium is influenced by cyclic nucleotides (cAMP and cGMP) content, which rating is governed by phosphodiesterases (PDEs) activity.Despite it has been demonstrated a beneficial effect of PDEs inhibitors in different pathological… read more here.
Keywords: camp cgmp; sulfhydration contributes; pdes activity; contractility ... See more keywords
Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042145
Abstract: Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates the second messenger cyclic AMP (cAMP), whereas activation of natriuretic peptide receptors and soluble… read more here.
Keywords: camp; camp cgmp; cardiac contractility; contractility ... See more keywords
Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158587
Abstract: 3’-5’ cyclic nucleotide phosphodiesterases (PDEs) are a family of evolutionary conserved cAMP and/or cGMP hydrolysing enzymes, components of transduction pathways regulating crucial aspects of cell life. Among them, cGMP-specific PDE5, being a regulator of vascular… read more here.
Keywords: metabolism modulated; localization; redox metabolism; cellular redox ... See more keywords
Functional characteristics and research trends of PDE11A in human diseases
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12814
Abstract: cAMP and cGMP are important secondary messengers involved in cell regulation and metabolism driven by the G protein-coupled receptor. cAMP is converted via adenylyl cyclase (AC) and activates protein kinase A to phosphorylate intracellular proteins… read more here.
Keywords: functional characteristics; disease; camp; expression ... See more keywords