An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14610
Abstract: The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the AGC‐kinase family. PKA‐C is a bilobal enzyme with a dynamic N‐lobe, harbouring the Adenosine‐5′‐triphosphate… read more here.
Keywords: cooperativity; protein kinase; kinase; camp dependent ... See more keywords
Quantitative phosphoproteomics reveals novel roles of cAMP in plants.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300165
Abstract: 3',5'-cyclic adenosine monophosphate (cAMP) is finally recognized as an essential signaling molecule in plants where cAMP-dependent processes include responses to hormones and environmental stimuli. To better understand the role of 3',5'-cAMP at the systems level,… read more here.
Keywords: quantitative phosphoproteomics; reveals novel; novel roles; camp ... See more keywords
cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102435
Abstract: Malaria remains a heavy global burden on human health, and it is important to understand the molecular and cellular biology of the parasite to find targets for drug and vaccine development. The mouse malaria model… read more here.
Keywords: camp dependent; dependent protein; yoelii; plasmodium yoelii ... See more keywords
Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12425-w
Abstract: Therapeutic activation of mitochondrial function has been suggested as an effective strategy to combat aging. Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer. Hydralazine has been recently shown… read more here.
Keywords: camp dependent; dependent protein; lifespan; activation ... See more keywords
cAMP‐Dependent Calcium Oscillations of Astrocytes: An Implication for Pathology
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhv310
Abstract: Abstract Astrocytes in various brain regions exhibit spontaneous intracellular calcium elevations both in vitro and in vivo; however, neither the temporal pattern underlying this activity nor its function has been fully evaluated. Here, we utilized… read more here.
Keywords: calcium oscillations; dependent calcium; pathology; camp dependent ... See more keywords
Involvement of the cAMP-Dependent Pathway in Dextromethorphan-Induced Inhibition of Spontaneous Glutamate Transmission in the Nucleus Tractus Solitarius Neurons of Guinea Pigs
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology"
DOI: 10.1159/000495295
Abstract: Dextromethorphan (DEX) presynaptically decreases glutamatergic transmission in second-order neurons of the nucleus tractus solitarius (TS). To clarify the inhibitory mechanism of DEX, the present study examined the interaction of DEX with cAMP. The effects of… read more here.
Keywords: camp; dex; dependent pathway; nucleus tractus ... See more keywords