Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway‐dependent manner in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14567
Abstract: Previously, we showed that an aberrant accumulation of activated Ras in mitochondria correlates with an increase in apoptosis. In this article, we show that lack of trehalose‐6P‐synthase, known to trigger apoptosis in Saccharomyces cerevisiae, induces localization… read more here.
Keywords: active ras2; pka pathway; regulated cell; mitochondria ... See more keywords
Adipose Secreted Slit2‐C Suppresses Breast Cancer Invasion Through cAMP/PKA Transition
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DOI: 10.1002/mc.23915
Abstract: Adipose tissue activation plays a positive role in breast cancer outcomes, consistent with the improved outcomes observed through exercise and weight loss mediated by brown and beige fat. However, the underlying mechanism of this process… read more here.
Keywords: cancer; camp pka; breast cancer; breast ... See more keywords
Mechanism of cAMP-PKA Signaling Pathway Mediated by Shaoyao Gancao Decoction (芍药甘草汤) on Regulation of Aquaporin 5 and Muscarinic Receptor 3 Levels in Sjögren’s Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-020-3205-5
Abstract: Objective To investigate the mechanism of cAMP-PKA signaling pathway mediated by Chinese medicine formula Shaoyao Gancao Decoction (芍药甘草汤, SGD) on the regulation of aquaporin 5 (AQP5) and muscarinic receptor 3 (M3R) levels in Sjögren’s syndrome… read more here.
Keywords: medicine; m3r; pka signaling; aqp5 m3r ... See more keywords
A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.02.048
Abstract: Summary Mitochondria play fundamental roles within cells, including energy provision, calcium homeostasis, and the regulation of apoptosis. The transport of mitochondria by microtubule-based motors is critical for neuronal structure and function. This process allows local… read more here.
Keywords: promotes axonal; transport; transport mitochondria; camp pka ... See more keywords
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174370
Abstract: Colorectal cancer (CRC) is the most fatal gastrointestinal tumor and it is urge to explore powerful drugs for the treatment. Diosgenin (DSG) as a new steroidal had been reported exerts anti-tumor activity in multiple cancers,… read more here.
Keywords: colorectal cancer; crc; pka creb; camp pka ... See more keywords
Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.08.006
Abstract: BACKGROUND Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet… read more here.
Keywords: guanosine; antithrombotic properties; activation; camp pka ... See more keywords
Mongolian Medicine Areca Thirteen Pill (GY-13) Improved Depressive Syndrome via upregulating cAMP/PKA/CREB/BDNF signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115310
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Areca Thirteen Pill, also called Gao You-13 (GY-13), is a traditional Mongolian herbal formula and has been extensively used to treat depression in Mongolian areas, which belongs to Heyi disease in Mongolian medicine.… read more here.
Keywords: bdnf; medicine; camp pka; depression ... See more keywords
Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2016.10.008
Abstract: In human adrenal, serotonin (5-HT), produced by mast cells located in zona glomerulosa, stimulates production of corticosteroids through a paracrine mechanism involving the 5-HT receptor type 4 (5-HT4). The aim of the present study was… read more here.
Keywords: adrenocortical cells; human adrenocortical; type calcium; calcium ... See more keywords
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101747
Abstract: Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the potential role and molecular basis of METRNL in doxorubicin (DOX)-induced… read more here.
Keywords: metrnl; camp pka; induced cardiotoxicity; dox ... See more keywords
Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-58682-w
Abstract: ANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+-dependent gating via… read more here.
Keywords: camp pka; pka; ano1; ca2 ... See more keywords
The cAMP-PKA signaling initiates mitosis by phosphorylating Bora
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63352-y
Abstract: Timely entry into mitosis requires activation of Polo-like kinase 1 (Plk1) by Aurora kinase A (Aurora A), but the upstream signaling trigger remains unclear. Here, we show that cyclic AMP (cAMP) signaling serves as a… read more here.
Keywords: camp pka; pka signaling; pka; mitosis ... See more keywords