Suppression of FoxO1 mRNA by β2‐adrenoceptor–cAMP signaling through miR‐374b‐5p and miR‐7a‐1‐3p in C2C12 myotubes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13368
Abstract: β2‐Adrenoceptor (β2‐AR) signaling decreases the transcriptional activity of forkhead box O (FoxO), but the underlying mechanisms remain incompletely understood. Here, we investigated how β2‐AR signaling regulates the protein abundance of FoxO and its transcriptional activity… read more here.
Keywords: foxo1 mrna; camp signaling; mir 374b; 374b mir ... See more keywords
microRNA‐665 silencing improves cardiac function in rats with heart failure through activation of the cAMP signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27987
Abstract: Heart failure (HF) is a disease with high mortality and morbidity rate. Previous studies have shown that microRNAs (miRNAs) may be implicated in the pathogenesis of HF, potentially being able to improve the cardiac function… read more here.
Keywords: signaling pathway; camp signaling; mir 665; cardiac function ... See more keywords
Quantitative Phosphoproteomics to Study cAMP Signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2245-2_18
Abstract: Cyclic adenosine monophosphate (cAMP) signaling activates multiple downstream cellular targets in response to different stimuli. Specific phosphorylation of key target proteins via activation of the cAMP effector protein kinase A (PKA) is achieved via signal… read more here.
Keywords: phosphoproteomics study; camp signaling; study camp; quantitative phosphoproteomics ... See more keywords
Mapping genetic changes in the cAMP-signaling cascade in human atria.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.02.006
Abstract: AIM To obtain a quantitative expression profile of the main genes involved in the cAMP-signaling cascade in human control atria and in different cardiac pathologies. METHODS AND RESULTS Expression of 48 target genes playing a… read more here.
Keywords: camp signaling; cascade human; atrial appendages; expression ... See more keywords
Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14501-x
Abstract: The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely… read more here.
Keywords: cyclase toxin; camp signaling; adenylate cyclase; toxin ... See more keywords
Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71522-9
Abstract: DNA double-strand breaks (DSB) are formed by various exogenous and endogenous factors and are repaired by homologous recombination and non-homologous end joining (NHEJ). DNA-dependent protein kinase (DNA-PK) is the principal enzyme for NHEJ. We explored… read more here.
Keywords: inhibition; gamma ray; dna; camp signaling ... See more keywords
Functional characterization of cAMP signaling of variant porcine MC1R alleles in PK15 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Animal genetics"
DOI: 10.1111/age.13189
Abstract: The melanocortin 1 receptor (MC1R), encoded by the classical extension (E) coat color locus, is expressed on the surface of melanocytes and plays a critical role in switching melanin synthesis from pheomelanin (red/yellow) to eumelanin… read more here.
Keywords: mc1r alleles; variant porcine; mc1r; porcine mc1r ... See more keywords
Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add5799
Abstract: Cyclic adenosine 3′,5′-monophosphate (cAMP) is a key second messenger in cardiomyocytes responsible for transducing autonomic signals into downstream electrophysiological responses. Previous studies have shown intracellular heterogeneity and compartmentalization of cAMP signaling. However, whether cAMP signaling… read more here.
Keywords: sex dependent; repolarization; camp; heart ... See more keywords
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.ade3380
Abstract: G protein–coupled receptors (GPCRs) promote the expression of immediate early genes required for learning and memory. Here, we showed that β2-adrenergic receptor (β2AR) stimulation induced the nuclear export of phosphodiesterase 4D5 (PDE4D5), an enzyme that… read more here.
Keywords: camp; nuclear camp; nuclear export; memory ... See more keywords
Surface-Induced cAMP Signaling Requires Multiple Features of the Pseudomonas aeruginosa Type IV Pili
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00186-22
Abstract: Surface sensing by P. aeruginosa requires TFP. TFP plays a critical role in the induction of the second messenger cAMP upon surface contact; this second messenger is part of a larger cascade involved in the… read more here.
Keywords: camp; surface; second messenger; tfp ... See more keywords
Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00584-16
Abstract: ABSTRACT Hundreds of hormones and ligands stimulate cyclic AMP (cAMP) signaling in different tissues through the activation of G-protein-coupled receptors (GPCRs). Although the functions and individual effectors of cAMP signaling are well characterized in many… read more here.
Keywords: dreadd; knock mice; cyclic amp; camp signaling ... See more keywords