Phytochemical investigation on the fruits of Camptotheca acuminata and their chemotaxonomic significance
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Systematics and Ecology"
DOI: 10.1016/j.bse.2020.104169
Abstract: Abstract A phytochemical investigation on the fruits of Camptotheca acuminata led to the isolation of 13 compounds, including five coumarins (1–5), two alkaloids (6 and 7), two triterpenoids (8 and 9), three lactones (10–12) and… read more here.
Keywords: investigation fruits; phytochemical investigation; acuminata chemotaxonomic; chemotaxonomic significance ... See more keywords
Genome-wide identification and analysis of AP2/ERF transcription factors related to camptothecin biosynthesis in Camptotheca acuminata.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)30070-4
Abstract: Camptotheca acuminata produces camptothecin (CPT), a monoterpene indole alkaloid (MIA) that is widely used in the treatment of lung, colorectal, cervical, and ovarian cancers. Its biosynthesis pathway has attracted significant attention, but the regulation of… read more here.
Keywords: biosynthesis; cacap2; analysis; ap2 ... See more keywords
Integrated transcriptome and proteome analysis provides new insights into camptothecin biosynthesis and regulation in Camptotheca acuminata.
Sign Up to like & getrecommendations! Published in 2023 at "Physiologia plantarum"
DOI: 10.1111/ppl.13916
Abstract: Camptotheca acuminata Decne., the main source of camptothecin (CPT), has received increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically used as effective anticancer agents worldwide. However, their biosynthesis mechanism remains unclear,… read more here.
Keywords: biosynthesis; integrated transcriptome; camptotheca acuminata; transcriptome proteome ... See more keywords
Effects of exogenous salicylic acid on accumulation of camptothecin and gene expression in Camptotheca acuminata
Sign Up to like & getrecommendations! Published in 2019 at "Canadian Journal of Forest Research"
DOI: 10.1139/cjfr-2018-0260
Abstract: Camptotheca acuminata Decne (Nyssaceae) is major natural source of camptothecin, an anticancer drug widely used for clinic therapy. Previous works have shown that many plant hormones or elicitors could regulate camptothecin biosynthesis, but few reports… read more here.
Keywords: expression; iridoids pathway; camptotheca acuminata; salicylic acid ... See more keywords
Predicting Suitable Habitats of Camptotheca acuminata Considering Both Climatic and Soil Variables
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DOI: 10.3390/f11080891
Abstract: Camptotheca acuminata is considered a natural medicinal plant with antitumor activity. The assessment of climate change impact on its suitable habitats is important for cultivation and conservation. In this study, we applied a novel approach… read more here.
Keywords: soil variables; predicting suitable; suitable habitats; climate change ... See more keywords
An ABCG-Type Transporter Facilitates ABA Influx and Regulates Camptothecin Biosynthesis in Camptotheca acuminata
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416120
Abstract: Camptothecin (CPT) and its derivatives from Camptotheca acuminata have antitumor effects as a DNA topoisomerase I inhibitor. Previous studies have shown that application of exogenous abscisic acid (ABA) significantly promoted the accumulation level of CPT… read more here.
Keywords: acuminata; biosynthesis; camptotheca acuminata; transporter ... See more keywords
Microwave-Assisted Extraction of Multiple Trace Levels of Intermediate Metabolites for Camptothecin Biosynthesis in Camptotheca acuminata and Their Simultaneous Determination by HPLC-LTQ-Orbitrap-MS/MS and HPLC-TSQ-MS
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24040815
Abstract: Camptothecin (CPT) has strong antitumor activity and is used as an anticancer therapeutic agent. To better understand and decipher the pathway of CPT biosynthesis in Camptotheca acuminata, the main purpose here was focused on creating… read more here.
Keywords: hplc; extraction; orbitrap; microwave assisted ... See more keywords