Self-Assembly of an Amphiphilic Janus Camptothecin-Floxuridine Conjugate into Liposome-Like Nanocapsules for More Efficacious Combination Chemotherapy in Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201703135
Abstract: The combination of camptothecin (CPT) and fluoropyrimidine derivatives acts synergistically at a 1:1 molar ratio. Practically, the greatest challenge is the development of a single liposomal formulation that can both encapsulate and maintain this drug… read more here.
Keywords: combination; camptothecin; liposome like; janus camptothecin ... See more keywords
The Plant Alkaloid Camptothecin as a Novel Antifouling Compound for Marine Paints: Laboratory Bioassays and Field Trials
Sign Up to like & getrecommendations! Published in 2018 at "Marine Biotechnology"
DOI: 10.1007/s10126-018-9834-4
Abstract: The extensive use of copper and booster biocides in antifouling (AF) paints has raised environmental concerns and the need to develop new AF agents. In the present study, 18 alkaloids derived from terrestrial plants were… read more here.
Keywords: laboratory bioassays; camptothecin; cpt; field ... See more keywords
A novel folic acid hydrogel loading β-cyclodextrin/camptothecin inclusion complex with effective antitumor activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-019-00962-2
Abstract: Abstract Folic acid, as a significant vitamin, is essential for human bodies, especially for pregnant women. However, folic acid hydrogel for drug delivery has not been reported until now. Herein, folic acid hydrogel was prepared… read more here.
Keywords: folic acid; inclusion; hydrogel; camptothecin ... See more keywords
Chitosan stabilized camptothecin nanoemulsions: Development, evaluation and biodistribution in preclinical breast cancer animal mode.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.127
Abstract: Clinical use of camptothecin (CPT) is hindered due to its poor water and oil solubility, active lactone ring instability and non-targeted toxicity. Recently we reported formulation of camptothecin microemulsions with increased solubility for the improved… read more here.
Keywords: biodistribution; breast; cpt; camptothecin ... See more keywords
Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.039
Abstract: In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αvβ3 with high affinity and specificity, was covalently conjugated to… read more here.
Keywords: microscopy; camptothecin; integrin targeted; tetrac conjugated ... See more keywords
Antitumor Effect of Peptide-Camptothecin Conjugate Targeting CD133 Protein.
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00485
Abstract: The peptide-drug conjugate (PDC) has emerged as one of the new approaches for cancer therapy, which has the advantages of improved drug target ability and reduced adverse effects compared with the traditional chemotherapy. CD133 is… read more here.
Keywords: cd133; cd133 protein; antitumor; camptothecin ... See more keywords
A Soluble Triantennary N-Acetylgalactosamine Camptothecin Prodrug for Hepatocellular Carcinoma-Targeted Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00466
Abstract: Camptothecin (CPT) and its derivatives are potent anticancer agents, but their clinical application is limited by poor aqueous solubility, lack of targeting specificity, and severe systemic toxicity. In this study, we synthesized a glycoconjugate prodrug,… read more here.
Keywords: cpt; triantennary acetylgalactosamine; hepatocellular carcinoma; galnac ... See more keywords
A Nitroreductase-Activated Chemiluminescent Prodrug for Real-Time Monitoring of Camptothecin Release in Peritoneal Metastasis Theranostics.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01674
Abstract: While most theranostic prodrugs utilize fluorescence for reporting, chemiluminescence offers superior signal-to-noise ratios. However, chemiluminescence-based prodrug systems remain relatively scarce. Herein, we report the development of CPT-NBz-CL, a novel hypoxia-responsive theranostic prodrug activated by nitroreductase… read more here.
Keywords: cpt nbz; chemiluminescence; peritoneal metastasis; camptothecin ... See more keywords
A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm00788g
Abstract: A camptothecin (CPT)-dilysine nanotube, stabilized with a layer of polydopamine (PDA), was functionalized on the surface with anti-TAG-72 antibody fragments. Cell viability studies showed that the presence of the targeting anti-TAG-72 scFv significantly enhanced cytotoxicity… read more here.
Keywords: cancer cells; nanoscale platform; modular nanoscale; tag ... See more keywords
Lipid-enveloped PLGA as a hybrid carrier for sustained delivering camptothecin in ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Iet Nanobiotechnology"
DOI: 10.1049/iet-nbt.2016.0141
Abstract: Camptothecin (CPT) is plant alkaloid exhibiting in a wide range of solid tumours. However, CPT was instability at physiological pH conditions, the lactone moieties easily hydrolysed makes systemic toxicity risky. Moreover, the water insolubility of… read more here.
Keywords: camptothecin; cpt; plga nps; ovarian cancer ... See more keywords
OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13377
Abstract: Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae… read more here.
Keywords: camptothecin; pumila; loganic acid; plant ... See more keywords