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Published in 2017 at "Advanced materials"
DOI: 10.1002/adma.201703135
Abstract: The combination of camptothecin (CPT) and fluoropyrimidine derivatives acts synergistically at a 1:1 molar ratio. Practically, the greatest challenge is the development of a single liposomal formulation that can both encapsulate and maintain this drug…
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Keywords:
combination;
camptothecin;
liposome like;
janus camptothecin ... See more keywords
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Published in 2018 at "Marine Biotechnology"
DOI: 10.1007/s10126-018-9834-4
Abstract: The extensive use of copper and booster biocides in antifouling (AF) paints has raised environmental concerns and the need to develop new AF agents. In the present study, 18 alkaloids derived from terrestrial plants were…
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Keywords:
laboratory bioassays;
camptothecin;
cpt;
field ... See more keywords
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Published in 2019 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-019-00962-2
Abstract: Abstract Folic acid, as a significant vitamin, is essential for human bodies, especially for pregnant women. However, folic acid hydrogel for drug delivery has not been reported until now. Herein, folic acid hydrogel was prepared…
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Keywords:
folic acid;
inclusion;
hydrogel;
camptothecin ... See more keywords
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Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.127
Abstract: Clinical use of camptothecin (CPT) is hindered due to its poor water and oil solubility, active lactone ring instability and non-targeted toxicity. Recently we reported formulation of camptothecin microemulsions with increased solubility for the improved…
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Keywords:
biodistribution;
breast;
cpt;
camptothecin ... See more keywords
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Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.039
Abstract: In this study, we prepared tetraiodothyroacetic acid (tetrac) conjugated PEG-PLGA polymersomes for the targeted delivery of camptothecin to colon adenocarcinoma. Tetrac, which binds to integrin αvβ3 with high affinity and specificity, was covalently conjugated to…
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Keywords:
microscopy;
camptothecin;
integrin targeted;
tetrac conjugated ... See more keywords
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Published in 2017 at "Iet Nanobiotechnology"
DOI: 10.1049/iet-nbt.2016.0141
Abstract: Camptothecin (CPT) is plant alkaloid exhibiting in a wide range of solid tumours. However, CPT was instability at physiological pH conditions, the lactone moieties easily hydrolysed makes systemic toxicity risky. Moreover, the water insolubility of…
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Keywords:
camptothecin;
cpt;
plga nps;
ovarian cancer ... See more keywords
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Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13377
Abstract: Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae…
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Keywords:
camptothecin;
pumila;
loganic acid;
plant ... See more keywords
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Published in 2019 at "Canadian Journal of Forest Research"
DOI: 10.1139/cjfr-2018-0260
Abstract: Camptotheca acuminata Decne (Nyssaceae) is major natural source of camptothecin, an anticancer drug widely used for clinic therapy. Previous works have shown that many plant hormones or elicitors could regulate camptothecin biosynthesis, but few reports…
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Keywords:
expression;
iridoids pathway;
camptotheca acuminata;
salicylic acid ... See more keywords
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Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-0028
Abstract: Contrary to other anticancer targets, topoisomerase I (TOP1) is targeted by only one chemical class of FDA-approved drugs: topotecan and irinotecan, the derivatives of the plant alkaloid, camptothecin. The indenoisoquinolines LMP400, LMP744, and LMP776 are…
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Keywords:
camptothecin;
novel fluoroindenoisoquinoline;
fluoroindenoisoquinoline non;
non camptothecin ... See more keywords
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Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0526
Abstract: We have developed a highly active and well-tolerated camptothecin (CPT) drug-linker designed for antibody-mediated drug delivery in which the lead molecule consists of a 7-aminomethyl-10,11-methylenedioxy CPT (CPT1) derivative payload attached to a novel hydrophilic protease-cleavable…
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Keywords:
development novel;
drug linker;
drug;
antibody ... See more keywords
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Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1737
Abstract: Multiple Myeloma (MM) is a recurring-relapsing plasma cell malignancy, which invariably develops drug resistance. Acquired resistance often involves mutation of drug targets or activation of compensatory pathways, making new targets in high demand. Physical contact…
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Keywords:
cpt;
camptothecin;
vla4;
drug ... See more keywords