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   Articles with "cana" as a keyword



Modulation of AMPK by esomeprazole and canagliflozin mitigates methotrexate-induced hepatotoxicity: involvement of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt signaling pathways

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recommendations! Published in 2025 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-025-03908-3

Abstract: This research investigated the hepatoprotective effects of esomeprazole (ESOM) and canagliflozin (CANA) against methotrexate-induced liver toxicity, focusing on AMPK modulation and its regulation of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt pathways. Fifty male Wistar rats were divided… read more here.

Keywords: cana; pi3k akt; jak1 stat3; esom cana ... See more keywords

Canagliflozin potentially promotes renal protection against glycerol-induced acute kidney injury by activating the AMPK/SIRT1/FOXO-3a/PGC-1α and Nrf2/HO-1 pathways

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recommendations! Published in 2025 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-025-04017-x

Abstract: The reno-protective potential of canagliflozin (Cana), an inhibitor of the sodium glucose–linked co-transporter-2 (SGLT-2), has been demonstrated in different models of kidney injury. However, its potential role in preventing glycerol (Gly)-induced acute kidney injury (AKI)… read more here.

Keywords: kidney injury; cana; sirt1; pgc ... See more keywords

CANA v1.0.0: efficient quantification of canalization in automata networks

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recommendations! Published in 2025 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btaf461

Abstract: Abstract Summary The biomolecular networks underpinning cell function exhibit canalization, or the buffering of fluctuations required to function in a noisy environment. We present a new major release of CANA, v1.0.0, an open-source Python package… read more here.

Keywords: https github; canalization automata; symmetry; cana ... See more keywords

4328Short-term effects of dapagliflozin versus canagliflozin on acute decompensated heart failure in patients with type 2 diabetes

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recommendations! Published in 2019 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehz745.0165

Abstract: The CANVAS program and DECLERE-TIMI 58 reported that SGLT2i had been demonstrated to reduce hospitalization for heart failure (HF) in type 2 diabetic mellitus (T2DM) patients with high cardiovascular disease risk. However, it remains unclear… read more here.

Keywords: heart; volume; cana; dapa ... See more keywords

Fourier Transform Infrared Spectroscopic, Spectrofluorimetric Assays of Canagliflozin, and Stability-Indicating UV-Spectrophotometric Method for the Simultaneous Determination of Canagliflozin and Metformin.

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recommendations! Published in 2022 at "Journal of AOAC International"

DOI: 10.1093/jaoacint/qsac030

Abstract: BACKGROUND Green Fourier transform infrared (FTIR) spectroscopy, using potassium bromide (KBr) disc technique, eliminates the consumption of hazardous chemicals. Spectrofluorimetry for drugs that have native fluorescence. Mean centering of ratio spectra (MCRS) analysing overlapped spectra… read more here.

Keywords: stability indicating; spectroscopy; determination; method ... See more keywords

SO021EFFECTS OF SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITOR, CANAGLIFLOZIN ON GLOMERULAR HYPERFILTRATION AND OXIDATIVE STRESS IN MICE WITH TYPE 2 DIABETES

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa139.so021

Abstract: In most developed countries, diabetic kidney disease (DKD) is the most common cause of chronic kidney disease, which can lead to end-stage renal disease. In recent clinical trials, sodium–glucose cotransporter 2 inhibitors (SGLT2is) slowed the… read more here.

Keywords: cana; glomerular hyperfiltration; mice; oxidative stress ... See more keywords

Eficácia dos extratos pirolenhosos de cana-de-açúcar (Saccharum officinarum L.) e eucalipto (Eucalyptus spp.) no controle in vitro de patógenos da soja

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recommendations! Published in 2021 at "Summa Phytopathologica"

DOI: 10.1590/0100-5405/182794

Abstract: O Brasil e segundo maior produtor mundial de soja [Glycine max (L.) Merr.], que possui grande importância no mercado pela expressiva participacao no contexto socioeconomico do Pais. Perdas na producao ocorrem devido ao ataque de… read more here.

Keywords: eucalipto; sclerotinia sclerotiorum; sclerotinia; extratos ... See more keywords

Overall Safety of Canagliflozin (CANA) in the CANagliflozin CardioVascular Assessment Study (CANVAS) Program

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recommendations! Published in 2018 at "Diabetes"

DOI: 10.2337/db18-259-or

Abstract: CANA is an SGLT2 inhibitor that was generally well tolerated in 12 placebo (PBO) and active-controlled phase 3/4 trials (non-CANVAS studies [NCS]) for ≤104 weeks in a broad range of patients with type 2 diabetes… read more here.

Keywords: canvas program; cana; safety; program ... See more keywords

Canagliflozin Prevents Lipid Accumulation, Mitochondrial Dysfunction, and Gut Microbiota Dysbiosis in Mice With Diabetic Cardiovascular Disease

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.839640

Abstract: Type 2 diabetes mellitus (T2DM) is associated with cardiovascular disease (CVD) and sodium glucose cotransporter 2 inhibitors, as oral medications for T2DM treatment have shown the potential to improve vascular dysfunction. The aim of this… read more here.

Keywords: cardiovascular disease; mice diabetic; treatment; cana ... See more keywords