Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.087676
Abstract: Human hepatoma cell lines are useful for evaluation of drug-induced hepatotoxicity, hepatic drug disposition, and drug-drug interactions. However, their applicability is compromised by aberrant expression of hepatobiliary transporters. This study was designed to evaluate whether… read more here.
Keywords: canalicular abc; huh; drug; huh cells ... See more keywords
Molecular Regulation of Canalicular ABC Transporters
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DOI: 10.3390/ijms22042113
Abstract: The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these transporters, ABCB11… read more here.
Keywords: molecular regulation; abc transporters; regulation canalicular; canalicular abc ... See more keywords