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Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.087676
Abstract: Human hepatoma cell lines are useful for evaluation of drug-induced hepatotoxicity, hepatic drug disposition, and drug-drug interactions. However, their applicability is compromised by aberrant expression of hepatobiliary transporters. This study was designed to evaluate whether…
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Keywords:
canalicular abc;
huh;
drug;
huh cells ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042113
Abstract: The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these transporters, ABCB11…
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Keywords:
molecular regulation;
abc transporters;
regulation canalicular;
canalicular abc ... See more keywords