Cancer‐associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: Potential role of ADAM9
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33947
Abstract: The tumor microenvironment plays a key role in cancer aggressiveness. Desmoplastic reaction (DR), morphologically classified as Mature, Intermediate and Immature types, has previously been shown to be highly prognostic in colorectal cancer (CRC) and it… read more here.
Keywords: crc; colorectal cancer; cancer associated; tumor ... See more keywords
HPV-induced Nurr1 promotes cancer aggressiveness, self-renewal, and radioresistance via ERK and AKT signaling in cervical cancer.
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DOI: 10.1016/j.canlet.2020.09.025
Abstract: Human papillomavirus (HPV) is the etiological agent of cervical cancer; however, the mechanisms underlying HPV-mediated carcinogenesis remain poorly understood. Here, we showed that nuclear receptor related-1 protein (Nurr1) was upregulated in primary cervical cancer tissue-derived… read more here.
Keywords: nurr1 promotes; cancer aggressiveness; radioresistance; cervical cancer ... See more keywords
Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling
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DOI: 10.1016/j.ebiom.2019.04.001
Abstract: Background It is well-established that activation of nuclear factor-kappa B (NF-κB) signaling plays important roles in cancer development and progression. However, the underlying mechanism by which the NF-κB pathway is constitutively activated in cancer remains… read more here.
Keywords: pimreg; cancer aggressiveness; breast cancer; activation ... See more keywords
N(6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer
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DOI: 10.1080/21655979.2022.2088497
Abstract: ABSTRACT N(6)-methyladenosine (m6A)-modified microRNAs (miRNAs) are relevant to cancer progression. Also, although the involvement of miR-380-3p in regulating cancer progression in bladder cancer and neuroblastoma has been preliminarily explored, its role in other types of… read more here.
Keywords: pancreatic cancer; mir 380; progression; methyladenosine ... See more keywords
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness
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DOI: 10.15252/embr.202154042
Abstract: Aberrant activation of the hypoxia‐inducible transcription factor HIF‐1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely… read more here.
Keywords: hypoxia signaling; p53 deficiency; p53; zbtb2 ... See more keywords
Low-dose statin treatment increases prostate cancer aggressiveness
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DOI: 10.18632/oncotarget.22217
Abstract: Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could… read more here.
Keywords: cancer aggressiveness; treatment; increases prostate; prostate cancer ... See more keywords