A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.08.010
Abstract: We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode… read more here.
Keywords: analysis reveals; tgf superfamily; pan cancer; cancer analysis ... See more keywords
Oncogenic role of karyopherin α2 (KPNA2) in human tumors: A pan-cancer analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.104955
Abstract: BACKGROUND KPNA2, a nuclear export protein that plays an important role in tumorigenesis, is an emerging hotspot target in oncology. Despite increasing supporting evidence of its importance, no pan-cancer analysis, across multiple databases, is available… read more here.
Keywords: pan cancer; cancer analysis; expression; role ... See more keywords
Pan-cancer analysis of the metabolic reaction network.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.09.006
Abstract: Metabolic reprogramming is considered a hallmark of malignant transformation. However, it is not clear whether the network of metabolic reactions expressed by cancers of different origin differ from each other nor from normal human tissues.… read more here.
Keywords: normal tissues; pan cancer; network; cancer analysis ... See more keywords
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25432-7
Abstract: Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to predict and monitor immune checkpoint blockade (ICB) therapeutic efficacy across cancer types. Yet, limited data exist to show the relationship between ctDNA… read more here.
Keywords: associated pembrolizumab; pan cancer; cancer analysis; sensitivity ... See more keywords
Pan-cancer analysis of whole genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1969-6
Abstract: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and… read more here.
Keywords: pan cancer; cancer analysis; analysis whole; whole genomes ... See more keywords
The prognostic and immunological role of MYB: from bladder cancer validation to pan-cancer analysis
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience Reports"
DOI: 10.1042/bsr20222627
Abstract: Abstract Background: MYB proto-oncogene is verified as a transcription factor. Although emerging evidence showed that MYB plays a critical part in tumor progression and immunity, a systematic pan-cancer analysis of MYB still remains to be… read more here.
Keywords: pan cancer; myb; bladder cancer; cancer analysis ... See more keywords
Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene.
Sign Up to like & getrecommendations! Published in 2021 at "Cell cycle"
DOI: 10.1080/15384101.2021.1982494
Abstract: MYBL2 has been demonstrated to be an oncogene in some cancers, but there is no pan-cancer analysis at the macro level. We used multiple online or offline bioinformatic tools to examine the effects of MYBL2… read more here.
Keywords: mybl2; pan cancer; cancer analysis; level ... See more keywords
A pan-cancer analysis of the oncogenic role of YKT6 in human tumors
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033546
Abstract: YKT6, as a Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein with vesicle trafficking, plays an essential role in the development and progression of tumor. However, the gene of YKT6 has not been fully assessed… read more here.
Keywords: ykt6; role; pan cancer; tumor ... See more keywords
Pan-cancer analysis of aldolase B gene as a novel prognostic biomarker for human cancers
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033577
Abstract: Aldolase B (ALDOB) gene is essential for the process of glycolysis and differentially expressed in cancers. The aims of this study were to explore the potential role of ALDOB in pan-cancer, in order to deepen… read more here.
Keywords: aldob expression; pan cancer; analysis; cancer analysis ... See more keywords
Systematic Pan-Cancer Analysis of KLRB1 with Prognostic Value and Immunological Activity across Human Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5254911
Abstract: Introduction KLRB1 is a gene encoding CD161 expressed in NK cells and some T cell subsets. At present, KLRB1 is believed to affect tumorigenesis and development by regulating the cytotoxicity of NK cells in several… read more here.
Keywords: pan cancer; expression; cancer analysis; cancer ... See more keywords
Abstract 4330: Pan-cancer analysis reveals m6A modification is functionally important in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4330
Abstract: N 6 -Methyladenosine (m 6 A) is the most abundant post-transcriptional modification in mammalian RNA molecules and has a critical role in many diseases, including cancer. However, the systematic investigation of the role of m… read more here.
Keywords: pan cancer; cancer analysis; somatic mutations; cancer ... See more keywords