IFNγ and TNFα drive an inflammatory secretion profile in cancer‐associated fibroblasts from human non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2025 at "Febs Letters"
DOI: 10.1002/1873-3468.15083
Abstract: Cancer‐associated fibroblasts (CAFs) are the dominant nonmalignant component of the tumour microenvironment (TME). CAFs demonstrate a high level of inter‐ and intra‐tumour heterogeneity in solid tumours, though the drivers of CAF subpopulations are not fully… read more here.
Keywords: cancer; non small; cell; associated fibroblasts ... See more keywords
Cancer‐associated V‐ATPase induces delayed apoptosis of protumorigenic neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12630
Abstract: Tumors and neutrophils undergo an unexpected interaction, in which products released by tumor cells interact to support neutrophils that in turn support cancer growth, angiogenesis, and metastasis. A key protein that is highly expressed by… read more here.
Keywords: cancer; cancer associated; delayed apoptosis; protumorigenic neutrophils ... See more keywords
Enhancing cancer‐associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12917
Abstract: Most cancer‐related deaths result from the progressive growth of metastases. Patients with peritoneal metastatic (PM) colorectal cancer have reduced overall survival. Currently, it is still unclear why colorectal cancer (CRC) cells home to and proliferate… read more here.
Keywords: fatty acid; colorectal cancer; colon cancer; cancer ... See more keywords
Cancer‐associated fibroblast migration in non‐small cell lung cancers is modulated by increased integrin α11 expression
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DOI: 10.1002/1878-0261.12937
Abstract: Cancer‐associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated… read more here.
Keywords: cancer stroma; expression; non small; cancer ... See more keywords
LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13053
Abstract: Cancer-associated fibroblasts (CAFs) are a heterogenous cell population within the tumor microenvironment, and play an important role in tumor development. By regulating the heterogeneity of CAFs, transforming growth factor β (TGFβ) influences tumor development. Here,… read more here.
Keywords: associated fibroblasts; tgf; cancer associated; cell ... See more keywords
Analyzing the role of cancer-associated fibroblast activation on macrophage polarization.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13454
Abstract: Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model of murine mammary gland tumors, Snai1… read more here.
Keywords: cafs; polarization; cancer associated; tumor ... See more keywords
Indoleamine 2,3-dioxygenase 1 inhibition reverses cancer-associated fibroblast-mediated immunosuppression in high-grade serous ovarian cancer.
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DOI: 10.1002/2211-5463.70126
Abstract: Cancer-associated fibroblasts (CAFs) contribute to immunosuppression in the ovarian cancer microenvironment, partly through upregulation of indoleamine 2,3-dioxygenase 1 (IDO1). This study examined CAF-mediated suppression of T-cell function and the potential of IDO1 inhibition to reverse… read more here.
Keywords: cancer; inhibition; ovarian cancer; immunosuppression ... See more keywords
Interplay between Matrix Viscoelasticity and Integrin Engagement Modulates Cancer-Associated Fibroblast States.
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DOI: 10.1002/adhm.202500389
Abstract: With the recent advent of single‐cell transcriptomics, it is increasingly evident that cancer‐associated fibroblasts (CAFs) are heterogeneous and exist as different subsets. These distinct CAF subsets likely harbor unique functions, most of which have not… read more here.
Keywords: integrin engagement; viscoelasticity integrin; viscoelasticity; caf ... See more keywords
Rapid Capture of Cancer Extracellular Vesicles by Lipid Patch Microarrays.
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DOI: 10.1002/adma.202008493
Abstract: Extracellular vesicles (EVs) contain various bioactive molecules such as DNA, RNA, and proteins, and play a key role in the regulation of cancer progression. Furthermore, cancer-associated EVs carry specific biomarkers and can be used in… read more here.
Keywords: extracellular vesicles; associated evs; rapid capture; cancer ... See more keywords
Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma
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DOI: 10.1002/adma.202404784
Abstract: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the third leading cause for cancer‐related death worldwide. The tumor is difficult‐to‐treat due to its inherent resistance to chemotherapy. Antistromal therapy is… read more here.
Keywords: antistromal therapy; cancer; therapy; hepatocellular carcinoma ... See more keywords
An Explainable Graph Neural Framework to Identify Cancer‐Associated Intratumoral Microbial Communities
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DOI: 10.1002/advs.202403393
Abstract: Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis and treatment responses. However, the underlying relationships between intratumoral microbes and tumors remain poorly understood. Here, a MIcrobial Cancer‐association Analysis using… read more here.
Keywords: cancer; framework; graph neural; microbial communities ... See more keywords