Autophagy as a therapeutic target in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-01039-5
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterised by early metastasis and resistance to anti-cancer therapy, leading to an overall poor prognosis. Despite continued research efforts, no targeted therapy has yet shown meaningful efficacy in PDAC; mutations… read more here.
Keywords: autophagy therapeutic; pdac; cancer autophagy; cancer ... See more keywords
mTOR Pathways in Cancer and Autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers10010018
Abstract: TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a central regulator of cell growth, proliferation and survival in response to nutritional status, growth factor, and stress signals. It plays a crucial role in… read more here.
Keywords: mtor pathways; cancer autophagy; autophagy; tor ... See more keywords