A troubling lack of replicability for cancer biology studies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22639
Abstract: K AT E R Y N A K O N / S H U TT E R S TO C K .C O M I n November 2021, a collaborative effort called the Reproducibility Project:… read more here.
Keywords: research; replicability; replication; cancer biology ... See more keywords
Combretastatin analogues in cancer biology: A prospective view
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29342
Abstract: The stilbenoid combretastatin and its derivatives are potent inhibitors of angiogenesis and cell proliferation and induce apoptosis. They disrupt cytoskeletal dynamics and modulate cell morphology, motility, and invasion. Hence they have been viewed as potential… read more here.
Keywords: combretastatin analogues; biology; cancer biology; combretastatin ... See more keywords
Cancer biology deciphered by single-cell transcriptomic sequencing.
Sign Up to like & getrecommendations! Published in 2021 at "Protein & cell"
DOI: 10.1007/s13238-021-00868-1
Abstract: Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune, endothelial, and stromal cells. Cancer biology had been studied using bulk genomic and gene expression profiling, which however… read more here.
Keywords: single cell; cell transcriptomic; biology; cancer biology ... See more keywords
Understanding the Intersections between Metabolism and Cancer Biology
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2016.12.039
Abstract: Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical… read more here.
Keywords: intersections metabolism; metabolism; understanding intersections; biology ... See more keywords
Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.07.028
Abstract: New work shows that the actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of focal adhesions. Loss of this function in Apc mutant cells reduces directed cell migration, potentially explaining the… read more here.
Keywords: biology apc; apc delivers; biology; cancer biology ... See more keywords
Cancer biology: Messages in extracellular vesicles depend on centrosome number
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.01.057
Abstract: Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive activity… read more here.
Keywords: extracellular vesicles; biology messages; messages extracellular; biology ... See more keywords
Breast cancer: Biology, biomarkers, and treatments.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106535
Abstract: During the past recent years, various therapies emerged in the era of breast cancer. Breast cancer is a heterogeneous disease in which genetic and environmental factors are involved. Breast cancer stem cells (BCSCs) are the… read more here.
Keywords: biology biomarkers; breast cancer; biology; cancer biology ... See more keywords
Current and upcoming mitochondrial targets for cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.06.006
Abstract: Mitochondria are essential intracellular organelles that regulate energy metabolism, cell death, and signaling pathways that are important for cell proliferation and differentiation. Therefore, mitochondria are fundamentally implicated in cancer biology, including initiation, growth, metastasis, relapse,… read more here.
Keywords: therapy; current upcoming; biology; cancer biology ... See more keywords
SOX2 in development and cancer biology.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2019.08.007
Abstract: The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression… read more here.
Keywords: cancer; sox2 development; biology; cancer biology ... See more keywords
Cancer biology: Rogue metabolite halts DNA repair
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/542394c
Abstract: ancestor of all living vertebrates may have had gills, a finding that adds to a long-standing debate about the evolutionary history of gills. In jawless animals such as lampreys, gills form from the embryo's innermost… read more here.
Keywords: biology; biology rogue; cancer biology; rogue metabolite ... See more keywords
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02245-6
Abstract: Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the evolutionarily conserved CMGC protein kinase superfamily. Due to its localization on chromosome 21,… read more here.
Keywords: kinase; biology; kinase dyrk1a; cancer biology ... See more keywords