Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2021.100798
Abstract: Abstract Purpose We hypothesize treatment with nivolumab and stereotactic radiosurgery (SRS) will be feasible and well tolerated and may improve intracranial tumor control rates compared to SRS alone. Methods and Materials The study was designed… read more here.
Keywords: brain metastases; cancer brain; study; breast cancer ... See more keywords
Diagnostic Clinical Trials in Breast Cancer Brain Metastases: Barriers and Innovations.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical breast cancer"
DOI: 10.1016/j.clbc.2019.05.018
Abstract: Optimal treatment of breast cancer brain metastases (BCBM) is often hampered by limitations in diagnostic abilities. Developing innovative tools for BCBM diagnosis is vital for early detection and effective treatment. In this study we explored… read more here.
Keywords: cancer brain; bcbm diagnosis; cancer; breast cancer ... See more keywords
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases
Sign Up to like & getrecommendations! Published in 2022 at "npj Breast Cancer"
DOI: 10.1038/s41523-022-00404-2
Abstract: Breast cancer brain metastases (BCBM) are a common and devastating complication of metastatic breast cancer with conventional systemic therapies demonstrating limited effectiveness. Consequently, radiotherapy (RT) ± surgery remains the cornerstone of BCBM management. Because preclinical and clinical… read more here.
Keywords: tremelimumab; cancer brain; breast cancer; trastuzumab ... See more keywords
Acceptability of the Mantram Repetition Program to Reduce Stress in Adolescent Survivors of Pediatric Cancer or Brain Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of adolescent and young adult oncology"
DOI: 10.1089/jayao.2022.0035
Abstract: A mixed-methods approach was used to explore the acceptability of the Mantram Repetition Program (MRP) to reduce stress in adolescents with a history of pediatric cancer or brain tumor. Five male participants diagnosed at ages… read more here.
Keywords: pediatric cancer; adolescent survivors; mantram repetition; acceptability mantram ... See more keywords
CMET-11. IMPACT OF TUMOR SIZE AND MOLECULAR PROFILE ON LOCAL CONTROL IN PATIENTS WITH BREAST CANCER BRAIN METASTASES: UNDERSTANDING TUMOR BIOLOGY AND RADIOSURGERY DOSING
Sign Up to like & getrecommendations! Published in 2017 at "Neuro-oncology"
DOI: 10.1093/neuonc/nox168.160
Abstract: INTRODUCTION Studies in the breast cancer literature have demonstrated that recurrence rates after surgery and adjuvant whole-breast irradiation differ based on tumor subtype. The hypothesis of this study was to clarify the relationship between tumor… read more here.
Keywords: tumor biology; breast cancer; cancer brain; biology ... See more keywords
CMET-18. IMPACT OF KRAS MUTATION STATUS ON THE EFFICACY OF IMMUNOTHERAPY IN LUNG CANCER BRAIN METASTASES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.219
Abstract: Immunotherapy is increasingly used in patients with non-small cell lung cancer brain metastases (NSCLCBM). KRAS mutations are associated with worse prognosis and there is no FDA approved targeted therapy. KRAS mutations are associated with increased… read more here.
Keywords: status; immunotherapy; cancer brain; lung cancer ... See more keywords
Prostate cancer brain metastasis in a contemporary cohort.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e14011
Abstract: e14011Background: The rarity of brain metastases from prostate cancer (PCA) limits our understanding of the impact of modern treatments on its development. The potential impact of new, highly active hormonal agents in brain metastases is… read more here.
Keywords: prostate cancer; metastasis; cancer brain; brain metastasis ... See more keywords
Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine Connections"
DOI: 10.1530/ec-22-0382
Abstract: Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the… read more here.
Keywords: survivors childhood; safety; brain tumors; childhood cancer ... See more keywords
Niraparib as Maintenance Therapy in Germline ATM-mutated and Somatic BRCA2-mutated Ovarian Cancer with Brain Metastases: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s281302
Abstract: Abstract Brain metastases from epithelial ovarian cancer are very rare with an incidence of only 1–2.5%. Many therapeutic methods such as surgery, irradiation and chemotherapy do produce survival benefits, but the overall outcome remains unsatisfactory.… read more here.
Keywords: cancer brain; ovarian cancer; cancer; germline atm ... See more keywords
Small extracellular vesicles in breast cancer brain metastasis and the prospect of clinical application
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1162089
Abstract: Extracellular vesicles (EVs) are nanoscale extracellular particles that have received widespread scientific attention for carrying a variety of biomolecules such as nucleic acids and proteins and participating in the process of intercellular information exchange, making… read more here.
Keywords: metastasis; breast cancer; brain metastasis; cancer brain ... See more keywords
Screening and Identification of Novel Potential Biomarkers for Breast Cancer Brain Metastases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.784096
Abstract: Brain metastases represent a major cause of mortality among patients with breast cancer, and few effective targeted treatment options are currently available. Development of new biomarkers and therapeutic targets for breast cancer brain metastases (BCBM)… read more here.
Keywords: brain metastases; identification; brain; breast cancer ... See more keywords