A multimodal fusion network based on variational autoencoder for distinguishing SCLC brain metastases from NSCLC brain metastases
Sign Up to like & getrecommendations! Published in 2025 at "Medical Physics"
DOI: 10.1002/mp.17816
Abstract: Distinguishing small cell lung cancer brain metastases from non‐small cell lung cancer brain metastases in MRI sequence images is crucial for the accurate diagnosis and treatment of lung cancer brain metastases. Multi‐MRI modalities provide complementary… read more here.
Keywords: brain; brain metastases; cancer brain; lung cancer ... See more keywords
Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2021.100798
Abstract: Abstract Purpose We hypothesize treatment with nivolumab and stereotactic radiosurgery (SRS) will be feasible and well tolerated and may improve intracranial tumor control rates compared to SRS alone. Methods and Materials The study was designed… read more here.
Keywords: brain metastases; cancer brain; study; breast cancer ... See more keywords
Diagnostic Clinical Trials in Breast Cancer Brain Metastases: Barriers and Innovations.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical breast cancer"
DOI: 10.1016/j.clbc.2019.05.018
Abstract: Optimal treatment of breast cancer brain metastases (BCBM) is often hampered by limitations in diagnostic abilities. Developing innovative tools for BCBM diagnosis is vital for early detection and effective treatment. In this study we explored… read more here.
Keywords: cancer brain; bcbm diagnosis; cancer; breast cancer ... See more keywords
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases
Sign Up to like & getrecommendations! Published in 2022 at "npj Breast Cancer"
DOI: 10.1038/s41523-022-00404-2
Abstract: Breast cancer brain metastases (BCBM) are a common and devastating complication of metastatic breast cancer with conventional systemic therapies demonstrating limited effectiveness. Consequently, radiotherapy (RT) ± surgery remains the cornerstone of BCBM management. Because preclinical and clinical… read more here.
Keywords: tremelimumab; cancer brain; breast cancer; trastuzumab ... See more keywords
Cancer–stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2322688121
Abstract: Significance The development of HER2-targeted therapies significantly improved the clinical outcomes of patients with HER2-positive breast cancer, but brain metastasis remains a major clinical challenge. Understanding the underlying mechanisms will facilitate the development of more… read more here.
Keywords: cancer; resistance; breast cancer; cancer brain ... See more keywords
Acceptability of the Mantram Repetition Program to Reduce Stress in Adolescent Survivors of Pediatric Cancer or Brain Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of adolescent and young adult oncology"
DOI: 10.1089/jayao.2022.0035
Abstract: A mixed-methods approach was used to explore the acceptability of the Mantram Repetition Program (MRP) to reduce stress in adolescents with a history of pediatric cancer or brain tumor. Five male participants diagnosed at ages… read more here.
Keywords: pediatric cancer; adolescent survivors; mantram repetition; acceptability mantram ... See more keywords
CMET-11. IMPACT OF TUMOR SIZE AND MOLECULAR PROFILE ON LOCAL CONTROL IN PATIENTS WITH BREAST CANCER BRAIN METASTASES: UNDERSTANDING TUMOR BIOLOGY AND RADIOSURGERY DOSING
Sign Up to like & getrecommendations! Published in 2017 at "Neuro-oncology"
DOI: 10.1093/neuonc/nox168.160
Abstract: INTRODUCTION Studies in the breast cancer literature have demonstrated that recurrence rates after surgery and adjuvant whole-breast irradiation differ based on tumor subtype. The hypothesis of this study was to clarify the relationship between tumor… read more here.
Keywords: tumor biology; breast cancer; cancer brain; biology ... See more keywords
CMET-18. IMPACT OF KRAS MUTATION STATUS ON THE EFFICACY OF IMMUNOTHERAPY IN LUNG CANCER BRAIN METASTASES
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.219
Abstract: Immunotherapy is increasingly used in patients with non-small cell lung cancer brain metastases (NSCLCBM). KRAS mutations are associated with worse prognosis and there is no FDA approved targeted therapy. KRAS mutations are associated with increased… read more here.
Keywords: status; immunotherapy; cancer brain; lung cancer ... See more keywords
Roles of JUN and MMP1 in lung cancer brain metastases
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DOI: 10.1097/md.0000000000042254
Abstract: Lung cancer brain metastases refer to intracranial space-occupying lesions formed by the metastasis of tumor cells from the lung to the brain parenchyma or dissemination in the meninges. The datasets GSE200563 and GSE126548 for lung… read more here.
Keywords: cancer; cancer brain; lung; lung cancer ... See more keywords
FAM50A drives breast cancer brain metastasis through interaction with C9ORF78 to enhance ʟ-asparagine production
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt3075
Abstract: Elevated levels of asparagine, catalyzed by asparagine synthetase (ASNS), have been identified as a prerequisite for lung metastasis in breast cancer. However, the roles and regulatory mechanisms of ASNS in breast cancer brain metastasis (BCBM)… read more here.
Keywords: breast cancer; cancer; brain metastasis; cancer brain ... See more keywords
Density of tertiary lymphoid structures predicts clinical outcome in breast cancer brain metastasis
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-009232
Abstract: Background Patients with breast cancer brain metastases (BCBM) experience a rapid decline in their quality of life. Recently, tertiary lymphoid structures (TLSs), analogs of secondary lymphoid organs, have attracted extensive attention. However, the potential clinical… read more here.
Keywords: tertiary lymphoid; cancer; breast cancer; cancer brain ... See more keywords