A multicenter, open‐label, single‐arm study of anamorelin (ONO‐7643) in advanced gastrointestinal cancer patients with cancer cachexia
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DOI: 10.1002/cncr.32406
Abstract: Cancer cachexia is characterized by weight loss and is associated with increased morbidity and mortality in patients with cancer. Anamorelin (ONO‐7643; ANAM) is a novel and selective ghrelin receptor agonist that improves appetite, lean body… read more here.
Keywords: patients cancer; anamorelin ono; cancer cachexia; cancer ... See more keywords
A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in patients with cancer cachexia and low body mass index.
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DOI: 10.1002/cncr.34154
Abstract: BACKGROUND Cancer cachexia is a syndrome characterized by anorexia and decreased body weight. This study evaluated the efficacy and safety of anamorelin, an orally active, selective ghrelin receptor agonist, in patients with cancer cachexia and… read more here.
Keywords: cancer; body; cancer cachexia; patients cancer ... See more keywords
Adipose tissue dysfunction in cancer cachexia
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DOI: 10.1002/jcp.26811
Abstract: Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory organ consisting… read more here.
Keywords: cancer; dysfunction; cancer cachexia; adipose tissue ... See more keywords
The influence of different muscle mass measurements on the diagnosis of cancer cachexia
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DOI: 10.1002/jcsm.12200
Abstract: Progressive loss of muscle mass is a major characteristic of cancer cachexia. Consensus definitions for cachexia provide different options to measure muscle mass. This study describes the effect of different methods to determine muscle mass… read more here.
Keywords: muscle mass; muscle; cancer cachexia;
MT‐102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12537
Abstract: Cachexia, a common manifestation of malignant cancer, is associated with wasting of skeletal muscle and fat tissue. In this study, we investigated the effects of a new first in class anabolic catabolic transforming agent on… read more here.
Keywords: cachexia; tissue; cancer cachexia; cancer ... See more keywords
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12561
Abstract: Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle… read more here.
Keywords: muscle; muscle wasting; rage; cancer cachexia ... See more keywords
High levels of modified ceramides are a defining feature of murine and human cancer cachexia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12626
Abstract: Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome reducing the efficiency of anti‐cancer therapies, quality of life, and survival of cancer patients. In the past years, most studies focused on the identification of tumour and… read more here.
Keywords: high levels; modified ceramides; levels modified; cancer cachexia ... See more keywords
Cancer cachexia and skeletal muscle atrophy in clinical studies: what do we really know?
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DOI: 10.1002/jcsm.12633
Abstract: Research investigators have shown a growing interest in investigating alterations underlying skeletal muscle wasting in patients with cancer. However, skeletal muscle dysfunctions associated with cancer cachexia have mainly been studied in preclinical models. In the… read more here.
Keywords: skeletal muscle; clinical studies; muscle; cancer cachexia ... See more keywords
Biomarkers for cancer cachexia: where do we stand?
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DOI: 10.1002/jcsm.12641
Abstract: Cancer cachexia has been recognized as a major, life‐limiting complication in the treatment of cancer patients and is composed of distinctive stages: pre‐cachexia, cachexia, and refractory cachexia. An early diagnosis of cachexia, possibly in the… read more here.
Keywords: cachexia stand; biomarkers cancer; cachexia; cancer cachexia ... See more keywords
Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy
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DOI: 10.1002/jcsm.12758
Abstract: Cancer cachexia (CCx) is a multifactorial wasting disorder characterized by involuntary loss of body weight that affects many cancer patients and implies a poor prognosis, reducing both tolerance to and efficiency of anticancer therapies. Actual… read more here.
Keywords: pla2g7 levels; cachexia; circulating pla2g7; cancer cachexia ... See more keywords
Geriatric Nutrition Risk Index: Prognostic factor related to inflammation in elderly patients with cancer cachexia.
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DOI: 10.1002/jcsm.12800
Abstract: BACKGROUND Systemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The Geriatric Nutritional Risk Index (GNRI) is a simple and useful tool to assess these conditions, but its predictive… read more here.
Keywords: risk; patients cancer; gnri score; gnri ... See more keywords