Selective induction of cancer cell death by VDAC1‐based peptides and their potential use in cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12313
Abstract: Mitochondrial VDAC1 mediates cross talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+, and metabolites and serves as a key player in apoptosis. As such, VDAC1 is involved… read more here.
Keywords: cell death; vdac1 based; cancer cell; cancer ... See more keywords
SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13208
Abstract: Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration and metastasis… read more here.
Keywords: ovarian cancer; cancer; cancer cell; cell motility ... See more keywords
TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13215
Abstract: Transforming growth factor β (TGFβ) induces epithelial-mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal-epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization. Whether TGFβ promotes stemness and invasiveness simultaneously… read more here.
Keywords: mesenchymal transition; cancer cell; tgf; pro stemness ... See more keywords
CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13438
Abstract: Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive.… read more here.
Keywords: cell; cdk6; cancer cell; cyclin ... See more keywords
The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901410
Abstract: Powerful experimental tools have contributed a wealth of novel insight into cancer etiology from the organ to the subcellular levels. However, these advances in understanding have outpaced improvements in clinical outcomes. One possible reason for… read more here.
Keywords: microfluidic platforms; use microfluidic; cell extravasation; cancer cell ... See more keywords
NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202642
Abstract: Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are… read more here.
Keywords: inhibition; sensitivity; oxphos inhibition; cancer cell ... See more keywords
Divergent Syntheses of Near‐Infrared Light‐Activated Molecular Jackhammers for Cancer Cell Eradication
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405965
Abstract: Aminocyanines incorporating Cy7 and Cy7.5 moieties function as molecular jackhammers (MJH) through vibronic‐driven action (VDA). This mechanism, which couples molecular vibrational and electronic modes, results in picosecond‐scale concerted stretching of the entire molecule. When cell‐associated… read more here.
Keywords: cancer; molecular jackhammers; cell; cancer cell ... See more keywords
Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413439
Abstract: Extensive fibrous stroma plays an important role in gemcitabine (GEM) resistance. However, the mechanism by which pancreatic cancer cells interact with pancreatic stellate cells (PSCs) to promote GEM resistance remains unclear. This study investigates the… read more here.
Keywords: cancer; linc znf25; gem; cancer cell ... See more keywords
DeepCCDS: Interpretable Deep Learning Framework for Predicting Cancer Cell Drug Sensitivity through Characterizing Cancer Driver Signals
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DOI: 10.1002/advs.202416958
Abstract: Accurate characterization of cellular states is the foundation for precise prediction of drug sensitivity in cancer cell lines, which in turn is fundamental to realizing precision oncology. However, current deep learning approaches have limitations in… read more here.
Keywords: deep learning; cancer; drug; cancer cell ... See more keywords
Targeting the Notch1-YY1-ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T-Cell-Driven Cancer Cell Pyroptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512845
Abstract: Immunotherapy has shown a modest clinical benefit in advanced hepatocellular carcinoma (HCC), probably due to tumor immunosuppressive functions. Although Notch1 signaling has been implicated in tumor immune escape, its underlying mechanism is unclear. Here, Notch1… read more here.
Keywords: cell; hcc; cd8 cell; cancer cell ... See more keywords
Binuclear Ruthenium (II) Complexes Featuring Arylthiourea Ligands: Synthesis, Crystal Structure and Anticancer Assessment
Sign Up to like & getrecommendations! Published in 2025 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.70146
Abstract: A new set of arene binuclear Ru (II)complexes of the type [RuCl2(η6‐p‐cymene)(η2‐N^S‐aroylthiourea)] has been synthesised to examine the effect on the cytotoxicity against human cancer cell lines. The formation of all the complexes (TC1–TC3) has… read more here.
Keywords: ruthenium; cancer; cell lines; structure ... See more keywords