Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.18433
Abstract: Key Points Question Did enrollment to cancer clinical trials in a federally funded cooperative group change during the first full year of the COVID-19 pandemic? Findings By use of an interrupted time-series analysis of 29 398… read more here.
Keywords: cancer clinical; clinical trial; covid pandemic; year ... See more keywords
Association of Perceived Benefit or Burden of Research Participation With Participants’ Withdrawal From Cancer Clinical Trials
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.44412
Abstract: This survey study analyzes the association of patients' perceived benefits and burdens of research participation with retention in cancer clinical trials. read more here.
Keywords: cancer clinical; clinical trials; association; research participation ... See more keywords
A New Approach to Simplifying and Harmonizing Cancer Clinical Trials-Standardizing Eligibility Criteria.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.1664
Abstract: Importance Clinical trial sponsors rely on eligibility criteria to control the characteristics of patients in their studies, promote the safety of participants, and optimize the interpretation of results. However, in recent years, complex and often… read more here.
Keywords: cancer clinical; eligibility criteria; trial; clinical trials ... See more keywords
A prospective comparison of cancer clinical trial availability and enrollment among adolescents/young adults treated at an adult cancer hospital or affiliated children’s hospital
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31727
Abstract: Low cancer clinical trial (CCT) enrollment may contribute to survival disparities affecting adolescents and young adults (AYAs) (ages 15‐39 years). The objective of this study was to evaluate whether differences in CCT availability related to… read more here.
Keywords: clinical trial; adolescents young; enrollment; cancer clinical ... See more keywords
Validation of surrogate endpoints in cancer clinical trials via principal stratification with an application to a prostate cancer trial.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7318
Abstract: Increasing attention has been focused on the use and validation of surrogate endpoints in cancer clinical trials. Previous literature on validation of surrogate endpoints are classified into four approaches: the proportion explained approach; the indirect… read more here.
Keywords: surrogate endpoints; surrogate; endpoints cancer; validation surrogate ... See more keywords
Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1137-7
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors have attracted much attention as one of the major molecular-targeted therapeutics for inhibiting DNA damage response. The PARP inhibitor, olaparib, has been clinically applied for treating certain recurrent ovarian cancer… read more here.
Keywords: targeting dna; cancer clinical; advances targeting; ovarian cancer ... See more keywords
The Impact of COVID-19 on National Clinical Trials Network Breast Cancer Trials
Sign Up to like & getrecommendations! Published in 2021 at "Current Breast Cancer Reports"
DOI: 10.1007/s12609-021-00417-z
Abstract: The COVID-19 pandemic has had a devastating impact on virtually all aspects of the healthcare system, including oncology clinical trials. The purpose of this review is to describe the impact of the pandemic on national… read more here.
Keywords: impact covid; breast cancer; cancer clinical; clinical trials ... See more keywords
Cancer Clinical Trials: The Rear-View Mirror and the Crystal Ball
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.01.027
Abstract: Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes… read more here.
Keywords: view mirror; rear view; trials rear; cancer clinical ... See more keywords
Searching for cures: Inner-city and rural patients' awareness and perceptions of cancer clinical trials
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2016.12.004
Abstract: Fewer than 5% of cancer patients participate in clinical trials, making it challenging to test new therapies or interventions for cancer. Even within that small number, patients living in inner-city and rural areas are underrepresented… read more here.
Keywords: city rural; inner city; cancer clinical; clinical trials ... See more keywords
Ovarian Cancer: Clinical Trial Breakthroughs and Impact on Management.
Sign Up to like & getrecommendations! Published in 2019 at "Obstetrics and gynecology clinics of North America"
DOI: 10.1016/j.ogc.2018.09.005
Abstract: Ovarian cancer treatment continues to evolve. Despite aggressive surgery and chemotherapy, most women will ultimately die from disease. Improvement in disease control are due to the incorporation of molecular targeted agents and the adoption of… read more here.
Keywords: clinical trial; maintenance therapy; trial breakthroughs; cancer clinical ... See more keywords
Prostate cancer: Clinical hallmarks in whole cancer genomes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2017.45
Abstract: Fraser and colleagues describe the whole-genome sequencing (WGS) profiles of over 200 localized intermediate-risk prostate cancers. WGS has been widely used in research but not, thus far, in clinical settings. Herein, we consider the possible… read more here.
Keywords: clinical hallmarks; prostate cancer; cancer clinical; cancer ... See more keywords