Activity of regorafenib plus nivolumab
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-0389-8
Abstract: The multikinase inhibitor regorafenib has shown immunomodulatory activity when combined with immunecheckpoint inhibition (ICI) in mouse models of colorectal cancer (CRC); in humans, this synergistic activity could help to overcome lack of response to ICI.… read more here.
Keywords: plus nivolumab; gastric cancer; crc; cancer ... See more keywords
Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200265
Abstract: Abstract Colorectal cancer (CRC) is the third most common malignancy and one of the leading causes of cancer-related death among men worldwide. CRC is a multifactor digestive pathology, which is a huge problem faced not… read more here.
Keywords: cancer crc; crc; multiple signaling; signaling pathways ... See more keywords
Colorectal cancer (CRC) patients surveyed by 18FDGPET-CT (PET-CT): An open-label multicenter randomized trial (NCT 00624260).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3520
Abstract: 3520Background: Curative surgery is the best therapy of CRC and recurrences. We assessed whether adding semi-annual PET-CT to the usual surveillance would be cost-effective in high risk recurrent C... read more here.
Keywords: surveyed 18fdgpet; colorectal cancer; crc patients; crc ... See more keywords
SATB2 loss and the immune milieu of colorectal cancer (CRC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.3569
Abstract: 3569Background: SATB2 orchestrates gene expression by regulating higher-order chromatin structure. Antibody screening of 48 normal human tissues and 20 cancers, showed SATB2 as almost exclusively e... read more here.
Keywords: immune milieu; loss immune; colorectal cancer; satb2 loss ... See more keywords
Colorectal cancer (CRC) among very elderly ( > 80 yo) patients (pts): A Brazilian single institution cohort.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.4_suppl.507
Abstract: 507 Background: Approximately 60% of all cancers and 70% of the mortality occurs in pts aged 65 years and over. Despite that, there is a significant lack of evidence regarding the safety and efficacy of… read more here.
Keywords: age; colorectal cancer; crc among; crc ... See more keywords
An Analysis Regarding the Association Between Connexins and Colorectal Cancer (CRC) Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s361362
Abstract: Background Gap junctions, as one of the major ways to maintain social connections between cells, are now considered as one of the potential regulators of tumor metastasis. However, to date, studies on the relationship between… read more here.
Keywords: cancer crc; expression; analysis; colorectal cancer ... See more keywords
A Distinctive microRNA (miRNA) Signature in the Blood of Colorectal Cancer (CRC) Patients at Surgery
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092410
Abstract: Background: Liquid biopsy (LB) provides an examination of the peripheral blood of cancer patients for circulating tumor cells, cell-free nucleic acids and microRNAs (miRNAs) and is an established tool of precision medicine. Unlike most previous… read more here.
Keywords: colorectal cancer; blood; signature; cancer crc ... See more keywords
Neuropilin-1 as a Potential Biomarker of Prognosis and Invasive-Related Parameters in Liver and Colorectal Cancer: A Systematic Review and Meta-Analysis of Human Studies
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143455
Abstract: Simple Summary Neuropilin-1 (NRP1) is a transmembrane protein which has had recently increased interest from cancer researchers. Liver cancer and colorectal cancer (CRC) are two of the most frequent and deadly tumors worldwide. Here, we… read more here.
Keywords: liver cancer; colorectal cancer; cancer; cancer crc ... See more keywords
MicroRNAs miR-584-5p and miR-425-3p Are Up-Regulated in Plasma of Colorectal Cancer (CRC) Patients: Targeting with Inhibitor Peptide Nucleic Acids Is Associated with Induction of Apoptosis in Colon Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010128
Abstract: Simple Summary Starting from a list of nine miRNAs found to be dysregulated in the bloodstream of early-stage colon cancer (CRC) patients, the biological effects of the targeting of the most relevant up-regulated miRNAs with… read more here.
Keywords: cancer crc; crc; colon cancer; crc patients ... See more keywords
Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168470
Abstract: Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is a complex process involving genetic alterations in cancer… read more here.
Keywords: tumor associated; colorectal cancer; crc; cancer crc ... See more keywords