The balance between induction and inhibition of mevalonate pathway regulates cancer suppression by statins: A review of molecular mechanisms.
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DOI: 10.1016/j.cbi.2017.06.026
Abstract: Statins are widely used drugs for their role in decreasing cholesterol in hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA Reductase (HMGCR), the main enzyme of the cholesterol biosynthesis pathway, inhibit mevalonate pathway that… read more here.
Keywords: cancer developing; inhibition mevalonate; mevalonate pathway; mevalonate isoprenoid ... See more keywords