Helminth‐derived molecules inhibit colitis‐associated colon cancer development through NF‐κB and STAT3 regulation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32626
Abstract: Inflammation is currently considered a hallmark of cancer and plays a decisive role in different stages of tumorigenesis, including initiation, promotion, progression, metastasis and resistance to antitumor therapies. Colorectal cancer is a disease widely associated… read more here.
Keywords: colon; associated colon; colon cancer; colitis associated ... See more keywords
Long non‐coding RNA SNHG14 contributes to gastric cancer development through targeting miR‐145/SOX9 axis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26889
Abstract: This study aimed to elucidate the roles of long non‐coding RNA SNHG14 in gastric cancer development. LncRNA SNHG14 was markedly up‐regulated in gastric cancer tissues and cells. Knockdown of SNHG14 significantly inhibited SGC‐7901 cell viability,… read more here.
Keywords: 145 sox9; mir 145; gastric cancer; snhg14 ... See more keywords
The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis
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DOI: 10.1002/jcp.25665
Abstract: Microrchidia (MORC or MORC family CW‐type zinc finger protein), a highly conserved nuclear protein superfamily, is an interesting new player in signaling‐dependent chromatin remodeling and epigenetic regulation. MORC family proteins consist of MORC1, MORC2, MORC3,… read more here.
Keywords: morc family; role; cancer development;
The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27445
Abstract: MicroRNAs (miRNAs) regulate several biological and physiological processes in mammalian cells, including cellular proliferation, differentiation, apoptosis, and metabolism. Recent studies have confirmed the alteration of them during the cancer development. Matrix metalloproteinases (MMPs), belonging to… read more here.
Keywords: cancer; progression metastasis; expression; cancer development ... See more keywords
An Emerging Model for Cancer Development from a Tumor Microenvironment Perspective in Mice and Humans.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-35727-6_2
Abstract: In the past, cancer development was studied in terms of genetic mutations acquired in cancer cells at each stage of the development. We present an emerging model for cancer development in which the tumor microenvironment… read more here.
Keywords: cancer cells; cancer; stage; development ... See more keywords
E2F7, EREG, miR-451a and miR-106b-5p are associated with the cervical cancer development
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-018-5007-y
Abstract: PurposeWe aimed to seek the crucial genes or microRNAs (miRNA) correlated with the cervical cancer development.MethodsThe miRNA profiling GSE30656 and gene expression profiling GSE63514 were obtained from Gene Expression Omnibus database. Differentially expressed microRNAs (DEMiRs)… read more here.
Keywords: network; cervical cancer; mir 451a; mir 106b ... See more keywords
Antibiotic therapy is associated with an increased incidence of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-022-03998-z
Abstract: There is a growing body of evidence suggesting the decisive involvement of the human microbiome in cancer development. The consumption of antibiotics may fundamentally change the microbiome and thereby create a precancerous environment promoting cancer… read more here.
Keywords: incidence; consumption; cancer; cancer development ... See more keywords
SMAD2 rs4940086 heterozygosity increases the risk of cervical cancer development among the women in Bangladesh
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05572-7
Abstract: SMAD2 is a critical signal transducer molecule in the TGFβ- SMAD pathway which is also known for its tumor suppressor role. Genetic variations in SMAD2 render cells insensitive to its anti-proliferative signals leading to tumor… read more here.
Keywords: smad2 rs4940086; risk cervical; cervical cancer; cancer ... See more keywords
RSK2 and its binding partners in cell proliferation, transformation and cancer development
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-016-0880-z
Abstract: RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90RSK; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA),… read more here.
Keywords: rsk2; cell proliferation; cancer development;
Diverse roles of arrest defective 1 in cancer development.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of pharmacal research"
DOI: 10.1007/s12272-019-01195-0
Abstract: Arrest defective 1 is an acetyltransferase that acetylates N-terminal amino acid or internal lysine residues of its target proteins. By acetylating its target proteins, ARD1 plays roles in many cellular activities, including proliferation, differentiation, autophagy,… read more here.
Keywords: arrest defective; roles arrest; diverse roles; cancer ... See more keywords
Kallistatin suppresses cancer development by multi-factorial actions.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.03.011
Abstract: Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions.… read more here.
Keywords: kallistatin; cancer; factor; growth ... See more keywords