CRISPR base editing applications for identifying cancer-driving mutations
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200550
Abstract: CRISPR base editing technology is a promising genome editing tool as (i) it does not require a DNA template to introduce mutations and (ii) it avoids creating DNA double-strand breaks, which can lead to unintended… read more here.
Keywords: cancer driving; dna; crispr base; base ... See more keywords
Cancer-driving mutations are enriched in genic regions intolerant to germline variation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.01.07.475416
Abstract: Large reference datasets of protein-coding variation in human populations have allowed us to determine which genes and genic sub-regions are intolerant to germline genetic variation. There is also a growing number of genes implicated in… read more here.
Keywords: germline variation; cancer driving; variation; regions intolerant ... See more keywords
Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.710304
Abstract: Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or… read more here.
Keywords: signaling pathways; key players; cancer; driving signaling ... See more keywords