The many faces of cancer evolution
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102403
Abstract: Summary Cancer cells acquire genotypic and phenotypic changes over the course of the disease. A minority of these changes enhance cell fitness, allowing a tumor to evolve and overcome environmental constraints and treatment. Cancer evolution… read more here.
Keywords: evolution; faces cancer; cancer; cancer evolution ... See more keywords
The somatic molecular evolution of cancer: Mutation, selection, and epistasis.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2021.08.003
Abstract: Cancer progression has been attributed to somatic changes in single-nucleotide variants, copy-number aberrations, loss of heterozygosity, chromosomal instability, epistatic interactions, and the tumor microenvironment. It is not entirely clear which of these changes are essential… read more here.
Keywords: evolution; somatic molecular; biology; cancer ... See more keywords
The evolution of evolutionary processes in organismal and cancer evolution.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2021.08.008
Abstract: The evolution of early life and of contemporary viruses has been driven in significant part by random genetic mutations, while modern unicellular and organismal evolution primarily leverages evolved, efficient and active cell biology processes for… read more here.
Keywords: evolution; biology; cancer cell; cancer ... See more keywords
MesKit: a tool kit for dissecting cancer evolution of multi-region tumor biopsies through somatic alterations
Sign Up to like & getrecommendations! Published in 2021 at "GigaScience"
DOI: 10.1093/gigascience/giab036
Abstract: Abstract Background Multi-region sequencing (MRS) has been widely used to analyze intra-tumor heterogeneity (ITH) and cancer evolution. However, comprehensive analysis of mutational data from MRS is still challenging, necessitating complicated integration of a plethora of… read more here.
Keywords: meskit; cancer; cancer evolution; somatic alterations ... See more keywords
Quantification of neoantigen-mediated immunoediting in cancer evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3717
Abstract: Immunoediting includes three temporally distinct stages, termed elimination, equilibrium, and escape, and has been proposed to explain the interactions between cancer cells and the immune system during the evolution of cancer. However, the status of… read more here.
Keywords: quantification; neoantigen mediated; cancer evolution; cancer ... See more keywords
Abstract 108: Spatio-temporal view of malignant histogenesis and cancer evolution via formation of polyploid giant cancer cell
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-108
Abstract: To understand how malignant tumors develop from single cells, we used long-term, time-lapse, live-cell imaging to track the dynamics of the cell membrane, nucleus, spindle, and cell cycle regulators during the development of high-grade, serous,… read more here.
Keywords: cell; polyploid giant; cancer evolution; formation ... See more keywords
The role of physics in multiomics and cancer evolution
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1068053
Abstract: Complex interactions between the physical environment and phenotype of a tumour, and genomics, transcriptomics, proteomics and epigenomics, are increasingly known to have a significant influence on cancer development, progression and evolution. For example, mechanical stress… read more here.
Keywords: physics; cancer evolution; role physics; cancer ... See more keywords
Reviving the Autopsy for Modern Cancer Evolution Research
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13030409
Abstract: Simple Summary Medical autopsies have a long history, but are currently experiencing a revival in order to progress modern cancer evolution research. Research autopsies represent an unparalleled opportunity to collect large volumes of cancer tissue… read more here.
Keywords: evolution; evolution research; modern cancer; cancer ... See more keywords