Tankyrase as a Novel Molecular Target in Cancer and Fibrotic Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug targets"
DOI: 10.2174/1389450117666160715152503
Abstract: Tankyrases belong to a group of enzymes called poly ADP ribosyl polymerases (PARPs). With the advent of a new class of small molecule inhibitors of PARP for clinical use like OLAPARIB; that gained accelerated approval… read more here.
Keywords: tankyrase novel; target; cancer fibrosis; cancer ... See more keywords
Ligand-bound integrin αvβ6 internalisation and trafficking
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DOI: 10.3389/fcell.2022.920303
Abstract: The integrin αvβ6 is expressed at low levels in most normal healthy tissue but is very often upregulated in a disease context including cancer and fibrosis. Integrins use endocytosis and trafficking as a means of… read more here.
Keywords: cancer fibrosis; internalisation; bound integrin; ligand ... See more keywords
Hypoxia in Cancer and Fibrosis: Part of the Problem and Part of the Solution
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158335
Abstract: Adaptive responses to hypoxia are involved in the progression of lung cancer and pulmonary fibrosis. However, it has not been pointed out that hypoxia may be the link between these diseases. As tumors or scars… read more here.
Keywords: cancer; cancer fibrosis; hypoxia cancer; part ... See more keywords