Cancer Gene Discovery: Past to Present.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8967-6_1
Abstract: Cancer is a complex disease that originates from genetic changes leading to multiple phenotypic manifestations that ultimately result in suffering and death from cancer. Attempts have been made to define the phenotypic and genetic "hallmarks"… read more here.
Keywords: cancer; discovery past; cancer gene; gene discovery ... See more keywords
Polymeric micelles as mighty nanocarriers for cancer gene therapy: a review
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3273-1
Abstract: PurposeGene therapy has shown extensive potential to treat human diseases occurring from the defection of genes like various types of cancers. The cationic polymers, as non-viral gene carriers, offer the ability to engineer carrier systems… read more here.
Keywords: search; gene therapy; cancer gene; therapy ... See more keywords
Promising approaches of small interfering RNAs (siRNAs) mediated cancer gene therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144071
Abstract: RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of the promising tools is the Small interfering RNA (siRNA) molecules within a cellular component. Principally, siRNA mediated… read more here.
Keywords: therapy; mediated cancer; small interfering; cancer gene ... See more keywords
Imaging techniques: new avenues in cancer gene and cell therapy
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2016.61
Abstract: Cancer is one of the world’s most concerning health problems and poses many challenges in the range of approaches associated with the treatment of cancer. Current understanding of this disease brings to the fore a… read more here.
Keywords: imaging techniques; cancer gene; cancer; gene ... See more keywords
Double trouble for cancer gene
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaz4016
Abstract: Double mutations in an oncogene enhance tumor growth Cancer is predominantly a genetic disease. Numerous gain-of-function mutations and gene amplifications that promote cell growth and survival have been identified in human cancer genomes through the… read more here.
Keywords: trouble cancer; double trouble; cancer gene; cancer ... See more keywords
Germline cancer gene expression quantitative trait loci are associated with local and global tumor mutations.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-2624
Abstract: Somatic mutations drive cancer development and are relevant to patient responses to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these… read more here.
Keywords: expression; cancer gene; gene expression; tumor ... See more keywords
Targeting Tumor Neoangiogenesis via Targeted Adenoviral Vector to Achieve Effective Cancer Gene Therapy for Disseminated Neoplastic Disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-0768
Abstract: The application of cancer gene therapy has heretofore been restricted to local, or locoregional, neoplastic disease contexts. This is owing to the lack of gene transfer vectors, which embody the requisite target cell selectivity in… read more here.
Keywords: cancer gene; cancer; vector; gene therapy ... See more keywords
Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0219935
Abstract: Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing… read more here.
Keywords: information; cancer gene; gene census; missense mutations ... See more keywords
Efficient cancer gene therapy with a Del1 fragment administered by hypodermic injection in a mouse explanted tumor model
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/21914
Abstract: Background: Cancer gene therapy using non-viral vectors has potential therapeutic value because it can be used repeatedly for long periods with safety and low costs. It has been reported that gene therapy with an E3C1… read more here.
Keywords: therapy; cancer gene; gene therapy; fragment ... See more keywords
Aberrant Expression of Pseudogene-Derived lncRNAs as an Alternative Mechanism of Cancer Gene Regulation in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00138
Abstract: Transcriptome sequencing has led to the widespread identification of long non-coding RNAs (lncRNAs). Subsequently, these genes have been shown to hold functional importance in human cellular biology, which can be exploited by tumors to drive… read more here.
Keywords: cancer gene; expression; cancer; protein coding ... See more keywords
Machine Learning Heuristics on Gingivobuccal Cancer Gene Datasets Reveals Key Candidate Attributes for Prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122379
Abstract: Delayed cancer detection is one of the common causes of poor prognosis in the case of many cancers, including cancers of the oral cavity. Despite the improvement and development of new and efficient gene therapy… read more here.
Keywords: gene datasets; machine learning; cancer gene; gingivobuccal cancer ... See more keywords