Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0373
Abstract: Importance Knowledge about the spectrum of diseases associated with hereditary cancer syndromes may improve disease diagnosis and management for patients and help to identify high-risk individuals. Objective To identify phenotypes associated with hereditary cancer genes… read more here.
Keywords: pathogenic variants; cancer genes; variants hereditary; hereditary cancer ... See more keywords
Identification of Cancer Genes Based on De Novo Transposon Insertion Site Analysis Using RNA and DNA Sequencing.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8967-6_5
Abstract: Forward genetic insertional mutagenesis screens are used by many labs to identify candidate cancer genes. We and others have used the Sleeping Beauty DNA transposon to generate random mutations within the murine genome that cause… read more here.
Keywords: cancer genes; transposon insertion; dna sequencing; cancer ... See more keywords
Construction of a Pearson- and MIC-Based Co-expression Network to Identify Potential Cancer Genes.
Sign Up to like & getrecommendations! Published in 2021 at "Interdisciplinary sciences, computational life sciences"
DOI: 10.1007/s12539-021-00485-w
Abstract: The weighted gene co-expression network analysis (WGCNA) method constructs co-expressed gene modules based on the linear similarity between paired gene expressions. Linear correlations are the main form of similarity between genes, however, nonlinear correlations still… read more here.
Keywords: cancer genes; network; potential cancer; expression network ... See more keywords
A computational approach for the discovery of significant cancer genes by weighted mutation and asymmetric spreading strength in networks
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02671-8
Abstract: Identifying significantly mutated genes in cancer is essential for understanding the mechanisms of tumor initiation and progression. This task is a key challenge since large-scale genomic studies have reported an endless number of genes mutated… read more here.
Keywords: cancer; asymmetric spreading; significant cancer; spreading strength ... See more keywords
Experimental validation of predicted cancer genes using FRET.
Sign Up to like & getrecommendations! Published in 2018 at "Methods and applications in fluorescence"
DOI: 10.1088/2050-6120/aab932
Abstract: Huge amounts of data are generated in genome wide experiments, designed to investigate diseases with complex genetic causes. Follow up of all potential leads produced by such experiments is currently cost prohibitive and time consuming.… read more here.
Keywords: cancer genes; experimental validation; predicted cancer; validation predicted ... See more keywords
Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2019-206400
Abstract: Aims Gastric cancer is one of the leading causes for cancer mortality. Recent studies have defined the landscape of genomic alterations of gastric cancer and their association with clinical outcomes. However, the pathogenesis of gastric… read more here.
Keywords: cancer genes; driver genes; values cases; gastric cancer ... See more keywords
Identification of Genes Universally Differentially Expressed in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/7326853
Abstract: Owing to the remarkable heterogeneity of gastric cancer (GC), population-level differentially expressed genes (DEGs) identified using case-control comparison cannot indicate the dysregulated frequency of each DEG in GC. In this work, first, the individual-level DEGs… read more here.
Keywords: cancer genes; gastric cancer; paired normal; cancer ... See more keywords
Abstract B10: CGNT: A database of cancer genes explored in a nontumoral context
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.tcm17-b10
Abstract: The new DNA and RNA sequencing platforms and the capability of analyzing tumor genomes allowed the identification of novel genes related to the process of human tumors appearance and maintenance, in addition to known cancer… read more here.
Keywords: cancer genes; cgnt; database; cancer ... See more keywords
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-16-1045
Abstract: Recent studies have characterized the extensive somatic alterations that arise during cancer. However, the somatic evolution of a tumor may be significantly affected by inherited polymorphisms carried in the germline. Here, we analyze genomic data… read more here.
Keywords: cancer genes; interaction landscape; somatic events; inherited polymorphisms ... See more keywords
Identifying Cancer genes by combining two-rounds RWR based on multiple biological data
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3123-8
Abstract: It’s a very urgent task to identify cancer genes that enables us to understand the mechanisms of biochemical processes at a biomolecular level and facilitates the development of bioinformatics. Although a large number of methods… read more here.
Keywords: cancer genes; seed; network; multiple biological ... See more keywords
Integrated genomic characterization of cancer genes in glioma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Cell International"
DOI: 10.1186/s12935-017-0458-y
Abstract: BackgroundCancers are caused by the acquisition of somatic mutations. Numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely known. This… read more here.
Keywords: cancer genes; driver; genes glioma; driver genes ... See more keywords