Investigation of Plasma cell‐free cancer genome chromosomal instability as a tool for targeted minimally invasive biomarkers for primary liver cancer diagnoses
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3142
Abstract: To characterize plasma cell‐free cancer genome chromosomal instabilities (CIN) in patients with liver cancer and to evaluate the potential of CIN as minimally invasive biomarkers for primary liver cancer (PLC) diagnoses. read more here.
Keywords: cancer genome; plasma cell; cell free; free cancer ... See more keywords
Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.001
Abstract: The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of… read more here.
Keywords: cancer genome; genome atlas; expression; cancer ... See more keywords
Upregulation of SLC2 (GLUT) family genes is related to poor survival outcomes in papillary thyroid carcinoma: Analysis of data from The Cancer Genome Atlas
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2016.04.050
Abstract: Background. The Warburg effect describes increased glucose uptake in cancer cells, and glucose transporter proteins are overexpressed in many tumors. In this study, we evaluated the expression of 14 SLC2A genes encoding glucose transporter proteins… read more here.
Keywords: papillary thyroid; thyroid carcinoma; expression; cancer genome ... See more keywords
Differential alternative RNA splicing and transcription events between tumors from African American and white patients in The Cancer Genome Atlas.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.02.020
Abstract: Individuals of African ancestry suffer disproportionally from higher incidence, aggressiveness, and mortality for particular cancers. This disparity likely results from an interplay among differences in multiple determinants of health, including differences in tumor biology. We… read more here.
Keywords: cancer genome; race; differential alternative; genome atlas ... See more keywords
Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology–molecular associations: clinical and biological implications
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.198
Abstract: The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor’s genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim… read more here.
Keywords: cancer genome; genome atlas; morphology; colorectal cancers ... See more keywords
Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25795
Abstract: Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for… read more here.
Keywords: pan cancer; cancer genome; transcriptome analyses; genome transcriptome ... See more keywords
Integrative reconstruction of cancer genome karyotypes using InfoGenomeR
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22671-6
Abstract: Annotation of structural variations (SVs) and base-level karyotyping in cancer cells remains challenging. Here, we present Integrative Framework for Genome Reconstruction (InfoGenomeR)-a graph-based framework that can reconstruct individual SVs into karyotypes based on whole-genome sequencing… read more here.
Keywords: cancer genome; integrative reconstruction; reconstruction cancer; cancer ... See more keywords
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01884-x
Abstract: ATM and ATR are conserved regulators of the DNA damage response linked to cancer. Comprehensive DNA sequencing efforts identified ~4,000 cancer-associated mutations in ATM/ATR; however, their cancer implications remain largely unknown. To gain insights, we… read more here.
Keywords: functional genetic; cancer genome; cancer; atm atr ... See more keywords
Latest Advance and Future Perspective for the Treatment of Metastatic Colorectal Cancer (mCRC)
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz365
Abstract: Abstract Several cancer genome alterations have been identified as important targets for mCRC treatment, which include BRAF mutation, HER-2 amplification/expression, microsatellite instability-high (MSI-H) and etc., for which corresponding agents showed promising activity in clinical trials.… read more here.
Keywords: cancer genome; mcrc; clinical development; treatment ... See more keywords
CGV: Cancer Genome Viewer, a web service for integrative cancer genome and pharmacogenomic data analysis
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac642
Abstract: MOTIVATION Multiomic profiling data, such as The Cancer Genome Atlas (TCGA) and pharmacogenomic data, facilitate research into cancer mechanisms and drug development. However, it is not easy for researchers to connect, integrate, and analyze huge… read more here.
Keywords: web service; pharmacogenomic data; cgv; cancer ... See more keywords
3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1078
Abstract: Abstract Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene expression.… read more here.
Keywords: cancer; comprehensive resource; cancer genome; genome 3div ... See more keywords