Germline gain‐of‐function MMP11 variant results in an aggressive form of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34289
Abstract: Matrix metalloproteinase‐11 (MMP11) is an enzyme with proteolytic activity against matrix and nonmatrix proteins. Although most MMPs are secreted as inactive proenzymes and are later activated extracellularly, MMP11 is activated intracellularly by furin within the… read more here.
Keywords: germline gain; cancer germline; mmp11; colorectal cancer ... See more keywords
A Cancer-Germline Antigen Signature Predicts Anti-CTLA4 Resistance.
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DOI: 10.1158/2159-8290.cd-rw2018-066
Abstract: High expression of the MAGE-A subcluster III is associated with anti-CTLA4 resistance in melanoma. read more here.
Keywords: cancer germline; anti ctla4; ctla4 resistance;
Outcome of patients with breast cancer and a germline BRCA mutation in a prospective cohort.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.1544
Abstract: 1544Background: There are limited large prospective single institution studies on outcome of breast cancer in patients with germline BRCA1 and BRCA2 mutation. The primary aim of this study was to d... read more here.
Keywords: patients breast; outcome patients; breast cancer; cancer ... See more keywords
Impact of Breast Cancer and Germline BRCA Pathogenic Variants on Fertility Preservation in Young Women
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DOI: 10.3390/life13040930
Abstract: Background: Several studies have suggested that breast cancer (BC) and germline BRCA pathogenic variants (gBRCA PVs) could have a deleterious impact on ovarian reserve. Nevertheless, data are limited and mixed. Our objective was to evaluate… read more here.
Keywords: pathogenic variants; germline brca; cancer germline; breast cancer ... See more keywords