Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12820
Abstract: Lung cancer is the leading cause of cancer‐related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha‐lipoic acid (LA), a drug used for treating human… read more here.
Keywords: cancer; cancer growth; mtor; lung cancer ... See more keywords
ALOX5‐5‐HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4066
Abstract: Recent studies highlight the regulatory role of arachidonate lipoxygenase5 (Alox5) and its metabolite 5‐hydroxyeicosatetraenoic acid (5‐HETE) in cancer tumorigenesis and progression. In this study, we analyzed the expression, biological function and the downstream signaling of… read more here.
Keywords: promotes gastric; hete promotes; gastric cancer; cancer ... See more keywords
High-fat diet promotes prostate cancer growth through histamine signaling.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.34028
Abstract: Western high-fat diets (HFD) are regarded as a major risk factor for prostate cancer (PCa). Using prostate-specific Pten-knockout mice as a PCa model, we previously reported that HFD promoted inflammatory PCa growth. The composition of… read more here.
Keywords: growth; high fat; cancer; prostate cancer ... See more keywords
13 C NMR Quantification of Polyamine Syntheses in Rat Prostate.
Sign Up to like & getrecommendations! Published in 2023 at "NMR in biomedicine"
DOI: 10.1002/nbm.4931
Abstract: BACKGROUND Currently, many prostate cancer patients, detected through the prostatic specific antigen test, harbor organ-confined indolent disease that cannot be differentiated from aggressive cancer according to clinically and pathologically known measures. Spermine has been considered… read more here.
Keywords: prostate cancer; prostate; cancer growth; syntheses rat ... See more keywords
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
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DOI: 10.1016/j.ccell.2017.09.008
Abstract: Reactive oxygen species (ROS) have emerged as important signaling molecules that play crucial roles in carcinogenesis and cytotoxic responses. Nrf2 is the master regulator of ROS balance. Thus, uncovering mechanisms of Nrf2 regulation is important… read more here.
Keywords: drug resistance; growth drug; keap1 binding; nrf2 keap1 ... See more keywords
FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.082
Abstract: Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (PPIase) FK506-binding… read more here.
Keywords: lung; translation; lung cancer; cancer ... See more keywords
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
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DOI: 10.1038/s41388-022-02203-2
Abstract: EGLN3 is critically important for growth of various cancers including lung cancer. However, virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in cancers. EGLN3 catalyzes the hydroxylation of extracellular signal-regulated… read more here.
Keywords: cancer; cancer growth; egln3 hydroxylase; egln3 ... See more keywords
The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00896-1
Abstract: PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor progression. Inhibition of DNA methyltransferases (DNMTs) leads to elevated hyaluronan levels; however, whether DNMT inhibitors control… read more here.
Keywords: pas1; breast cancer; growth metastasis; ph20 ... See more keywords
Abstract 1757: IFN-γ signaling in myeloid and fibroblastic cells regulates pancreatic cancer growth and metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1158/1538-7445.am2021-1757
Abstract: Pancreatic ductal adenocarcinoma (PDAC) represents a significant healthcare problem which is on the rise, primarily because of the late stage diagnosis, early metastasis, and rapidly emerging resistance to therapy. As cancer cells in a typical… read more here.
Keywords: metastasis; cancer growth; ifn signaling; cancer ... See more keywords
Depletion of C12orf48 inhibits gastric cancer growth and metastasis via up-regulating Poly r(C)-Binding Protein (PCBP) 1
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DOI: 10.1186/s12885-022-09220-0
Abstract: Background Gastric cancer remains a major cause of cancer-related death worldwide. C12orf48, also named PARP1 binding protein, is over-expressed in several cancers. However, the expression profile and potential roles of C12orf48 in gastric cancer are… read more here.
Keywords: cancer; binding protein; depletion c12orf48; c12orf48 ... See more keywords
Prediction of breast cancer growth rate In vivo and its clinical implications.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e12581
Abstract: e12581Background: Breast tumors have highly variable rates of growth. In vivo breast cancer growth rate is governed by number of inter-related clinicopathological and biological parameters and is strictly regulated. This study aimed to assess the… read more here.
Keywords: cancer growth; growth; growth rate; breast cancer ... See more keywords