Cancer heterogeneity is not compatible with one unique cancer cell metabolic map
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.411
Abstract: The Warburg effect and its accompanying metabolic features (anaplerosis, cataplerosis) are presented in textbooks and reviews as a hallmark (general characteristic): the metabolic map of cancer. On the other hand, research articles on specific tumors… read more here.
Keywords: cancer; cancer heterogeneity; metabolic map; map cancer ... See more keywords
The Roles of ROS in Cancer Heterogeneity and Therapy
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/2467940
Abstract: Cancer comprises a group of heterogeneous diseases encompassing high rates of morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main factors related to resistance to chemotherapeutic agents leading to… read more here.
Keywords: cancer heterogeneity; roles ros; heterogeneity therapy; heterogeneity ... See more keywords
DNA methylation profiles capturing breast cancer heterogeneity
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6142-y
Abstract: BackgroundAs one of the most described epigenetic marks in human cancers, DNA methylation plays essential roles in gene expression regulation and has been implicated in the prognosis and therapeutics of many cancers. We are motivated… read more here.
Keywords: cancer; cancer heterogeneity; dna methylation; breast cancer ... See more keywords
Colorectal Cancer Heterogeneity and the Impact on Precision Medicine and Therapy Efficacy
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DOI: 10.3390/biomedicines10051035
Abstract: Novel targeted therapies for metastatic colorectal cancer are needed to personalize treatments by guiding specific biomarkers selected on the genetic profile of patients. RAS and BRAF inhibitors have been developed for patients who become unresponsive… read more here.
Keywords: cancer heterogeneity; colorectal cancer; impact precision; heterogeneity impact ... See more keywords
Breast Cancer Heterogeneity and Response to Novel Therapeutics
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DOI: 10.3390/cancers12113271
Abstract: Simple Summary Breast cancer is a heterogeneous disease that is driven by genetic, epigenetic and phenotypic modifications and is also affected by the microenvironment and the metabolism. In this article we review genetic and non-genetic… read more here.
Keywords: cancer heterogeneity; heterogeneity response; heterogeneity; breast cancer ... See more keywords