A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
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DOI: 10.1101/2022.01.06.475190
Abstract: Cancer mutations in Ras occur predominantly at three hotspots: Gly 12, Gly 13, and Gln 61. Previously, we reported that deep mutagenesis of H-Ras using a bacterial assay identified many other activating mutations (Bandaru et… read more here.
Keywords: activation; cancer hotspots; stability; cancer ... See more keywords