Extracellular‐Vesicle‐Based Drug Delivery Systems for Enhanced Antitumor Therapies through Modulating the Cancer‐Immunity Cycle
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201054
Abstract: Although immunotherapy harnessing activity of the immune system against tumors has made great progress, the treatment efficacy remains limited in most cancers. Current anticancer immunotherapy is primarily based on T‐cell‐mediated cellular immunity, which highly relies… read more here.
Keywords: cancer immunity; immunity; immunity cycle; drug delivery ... See more keywords
T lymphocyte subsets in cancer immunity: Friends or foes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.mr0318-097r
Abstract: Although immune‐based therapy is proving to be a success in several cancer types, only a set of patients appear to respond to immune checkpoint blockade including PD‐1 and CTLA‐4. A better understanding of the crucial… read more here.
Keywords: subsets cancer; cancer immunity; cancer; immunity friends ... See more keywords
Cell-Based Drug Delivery Systems Participate in the Cancer Immunity Cycle for Improved Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202205166
Abstract: Immunotherapy aims to activate the cancer patient's immune system for cancer therapy. The whole process of the immune system against cancer referred to as the "cancer immunity cycle", gives insight into how drugs can be… read more here.
Keywords: cell based; cancer immunity; cancer; cancer immunotherapy ... See more keywords
Melanoma Cancer Immunotherapy Using PD-L1 siRNA and Imatinib Promotes Cancer-Immunity Cycle
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DOI: 10.1007/s11095-020-02838-4
Abstract: Purpose Cancer-Immunity Cycle is a cascade of anticancer immune responses in the body that continues and fights against the cancer expansion. The Cancer-Immunity Cycle is halted by tumor cell immunosuppression of host T cell through… read more here.
Keywords: immunity; immunity cycle; cancer immunity; cancer ... See more keywords
Symphony of nanomaterials and immunotherapy based on the cancer‒immunity cycle
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.031
Abstract: Abstract The immune system is involved in the initiation and progression of cancer. Research on cancer and immunity has contributed to the development of several clinically successful immunotherapies. These immunotherapies often act on a single… read more here.
Keywords: cancer; immunity cycle; cancer immunity; based cancer ... See more keywords
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Immunity"
DOI: 10.1016/j.immuni.2022.03.013
Abstract: Lymphocyte activation gene-3 (LAG-3) is a potent inhibitory co-receptor; yet, its functional ligand remains elusive, with distinct potential ligands identified. Here, we investigated the relative contribution of potential ligands, stable peptide-MHC class II complexes (pMHCII)… read more here.
Keywords: lag; stable pmhcii; cancer immunity; anti cancer ... See more keywords
NMT as a glycine and lysine myristoyltransferase in cancer, immunity, and infections.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00314
Abstract: Protein myristoylation, the addition of a 14-carbon saturated acyl group, is an abundant modification implicated in biological events as diverse as development, immunity, oncogenesis, and infections. N-myristoyltransferase (NMT) is the enzyme that catalyzes this modification.… read more here.
Keywords: immunity infections; cancer immunity; immunity; lysine myristoyltransferase ... See more keywords
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
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DOI: 10.1038/s41586-020-2015-4
Abstract: Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 , their roles in cancer immunity and immunotherapy… read more here.
Keywords: tissue specific; immunity; ilc2s; cancer immunity ... See more keywords
Intratumoral immunotherapy: using the tumor as the remedy
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DOI: 10.1093/annonc/mdx683
Abstract: Immune checkpoint-targeted monoclonal antibodies directed at Programmed Death Receptor 1 (PD-1), Programmed Death Ligand 1 (PD-L1) and Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4) are currently revolutionizing the prognosis of many cancers. By blocking co-inhibitory receptors… read more here.
Keywords: cancer immunity; cancer; intratumoral immunotherapy; immunotherapy using ... See more keywords
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004129
Abstract: Background LTX-315 is an oncolytic peptide deriving from bovine lactoferrin, with the ability to induce cancer immunogenic cell death. However, the mechanism used by LTX-315 to trigger the antitumor immune response is still poorly understood.… read more here.
Keywords: cancer; ltx 315; oncolytic peptide; cancer immunity ... See more keywords
Abstract 3716: RNA N6-methyladenosine binding protein, YTHDF1 regulates DNA repair and cancer immunity in protein synthesis levels
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3716
Abstract: N6-methyladenosine RNA methylation is one of the most abundant post transcriptional modifications in eukaryotic messenger RNAs and plays crucial roles in cancer development and progression. YTHDF1 is an m6A reader protein and has been reported… read more here.
Keywords: cancer immunity; ythdf1; protein; protein synthesis ... See more keywords